Adrenergic- and cyclic nucleotide-induced glycerol release from brown adipocytes

Jock Hamilton, Barbara A Horwitz

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Previous work has shown that although both α- and β-agonists stimulate brown fat heat production, the β-agonist is quantitatively more effective. The finding in the present study that isoproterenol, a β-agonist, significantly stimulates net glycerol release from isolated hamster brown adipocytes while the α-agonist, phenylephrine does not, may account (at least in part) for the differential thermogenic response to the two types of agents. The present study also compared lipolytic responses to AMP, cAMP, cGMP and theophylline, with the results indicating a greater rate of net glycerol release being induced by AMP and by cAMP than by theophylline or cGMP plus theophylline.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalEuropean Journal of Pharmacology
Volume56
Issue number1-2
DOIs
StatePublished - Jun 1 1979

Keywords

  • Brown adipose tissue
  • Catecholamines
  • Cyclic nucleotides
  • Glycerol release
  • Lipolysis
  • α-Adrenergic
  • β-Adrenergic

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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