Previous work has shown that although both α- and β-agonists stimulate brown fat heat production, the β-agonist is quantitatively more effective. The finding in the present study that isoproterenol, a β-agonist, significantly stimulates net glycerol release from isolated hamster brown adipocytes while the α-agonist, phenylephrine does not, may account (at least in part) for the differential thermogenic response to the two types of agents. The present study also compared lipolytic responses to AMP, cAMP, cGMP and theophylline, with the results indicating a greater rate of net glycerol release being induced by AMP and by cAMP than by theophylline or cGMP plus theophylline.
- Brown adipose tissue
- Cyclic nucleotides
- Glycerol release
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience