Adrenalectomy and Nephrectomy in a Rabbit (Oryctolagus cuniculus) With Adrenocortical Carcinoma and Renal and Ureteral Transitional Cell Carcinoma

Josephine B. Rose, Claire Vergneau-Grosset, Michele A Steffey, Eric G Johnson, Vivian S. Chen, Frederick C Mohr, Carolynn Harvey, David Guzman

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A 9-year-old neutered male rabbit (Oryctolagus cuniculus) previously diagnosed with right nephromegaly was presented with increased sexual behavior associated with hypertestosteronemia. Left adrenomegaly and an obstructive mass in the right renal pelvis and proximal ureter leading to severe hydronephrosis of the right kidney were diagnosed by abdominal ultrasound. A left adrenalectomy and right nephrectomy were performed and samples were submitted for histopathology, confirming the diagnosis of adrenocortical carcinoma and a transitional cell carcinoma of the ureter and renal pelvis. Increased sexual behavior resolved within 2 months following surgical resection of the affected left adrenal gland, but recurred 8 months later. The right adrenal gland had increased in size when compared to earlier ultrasonographic evalution. A 4.7-mg deslorelin implant was placed subcutaneously, which resulted in a decrease of testosteronemia and sexual behaviors for up to 18 months.

Original languageEnglish (US)
Pages (from-to)332-341
Number of pages10
JournalJournal of Exotic Pet Medicine
Volume25
Issue number4
DOIs
StatePublished - Oct 1 2016

Fingerprint

Adrenocortical Carcinoma
Oryctolagus cuniculus
Transitional Cell Carcinoma
Adrenalectomy
sexual behavior
Nephrectomy
Sexual Behavior
carcinoma
ureter
Kidney Pelvis
pelvis
rabbits
adrenal glands
kidneys
Ureter
Adrenal Glands
Rabbits
Kidney
Hydronephrosis
resection

Keywords

  • adrenocortical carcinoma
  • deslorelin
  • GnRH agonist
  • hypertestosteronism
  • rabbit
  • renal transitional cell carcinoma

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Adrenalectomy and Nephrectomy in a Rabbit (Oryctolagus cuniculus) With Adrenocortical Carcinoma and Renal and Ureteral Transitional Cell Carcinoma. / Rose, Josephine B.; Vergneau-Grosset, Claire; Steffey, Michele A; Johnson, Eric G; Chen, Vivian S.; Mohr, Frederick C; Harvey, Carolynn; Guzman, David.

In: Journal of Exotic Pet Medicine, Vol. 25, No. 4, 01.10.2016, p. 332-341.

Research output: Contribution to journalArticle

@article{080cfd09d1974a26a022e9675fa7ae32,
title = "Adrenalectomy and Nephrectomy in a Rabbit (Oryctolagus cuniculus) With Adrenocortical Carcinoma and Renal and Ureteral Transitional Cell Carcinoma",
abstract = "A 9-year-old neutered male rabbit (Oryctolagus cuniculus) previously diagnosed with right nephromegaly was presented with increased sexual behavior associated with hypertestosteronemia. Left adrenomegaly and an obstructive mass in the right renal pelvis and proximal ureter leading to severe hydronephrosis of the right kidney were diagnosed by abdominal ultrasound. A left adrenalectomy and right nephrectomy were performed and samples were submitted for histopathology, confirming the diagnosis of adrenocortical carcinoma and a transitional cell carcinoma of the ureter and renal pelvis. Increased sexual behavior resolved within 2 months following surgical resection of the affected left adrenal gland, but recurred 8 months later. The right adrenal gland had increased in size when compared to earlier ultrasonographic evalution. A 4.7-mg deslorelin implant was placed subcutaneously, which resulted in a decrease of testosteronemia and sexual behaviors for up to 18 months.",
keywords = "adrenocortical carcinoma, deslorelin, GnRH agonist, hypertestosteronism, rabbit, renal transitional cell carcinoma",
author = "Rose, {Josephine B.} and Claire Vergneau-Grosset and Steffey, {Michele A} and Johnson, {Eric G} and Chen, {Vivian S.} and Mohr, {Frederick C} and Carolynn Harvey and David Guzman",
year = "2016",
month = "10",
day = "1",
doi = "10.1053/j.jepm.2016.06.010",
language = "English (US)",
volume = "25",
pages = "332--341",
journal = "Journal of Exotic Pet Medicine",
issn = "1557-5063",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Adrenalectomy and Nephrectomy in a Rabbit (Oryctolagus cuniculus) With Adrenocortical Carcinoma and Renal and Ureteral Transitional Cell Carcinoma

AU - Rose, Josephine B.

AU - Vergneau-Grosset, Claire

AU - Steffey, Michele A

AU - Johnson, Eric G

AU - Chen, Vivian S.

AU - Mohr, Frederick C

AU - Harvey, Carolynn

AU - Guzman, David

PY - 2016/10/1

Y1 - 2016/10/1

N2 - A 9-year-old neutered male rabbit (Oryctolagus cuniculus) previously diagnosed with right nephromegaly was presented with increased sexual behavior associated with hypertestosteronemia. Left adrenomegaly and an obstructive mass in the right renal pelvis and proximal ureter leading to severe hydronephrosis of the right kidney were diagnosed by abdominal ultrasound. A left adrenalectomy and right nephrectomy were performed and samples were submitted for histopathology, confirming the diagnosis of adrenocortical carcinoma and a transitional cell carcinoma of the ureter and renal pelvis. Increased sexual behavior resolved within 2 months following surgical resection of the affected left adrenal gland, but recurred 8 months later. The right adrenal gland had increased in size when compared to earlier ultrasonographic evalution. A 4.7-mg deslorelin implant was placed subcutaneously, which resulted in a decrease of testosteronemia and sexual behaviors for up to 18 months.

AB - A 9-year-old neutered male rabbit (Oryctolagus cuniculus) previously diagnosed with right nephromegaly was presented with increased sexual behavior associated with hypertestosteronemia. Left adrenomegaly and an obstructive mass in the right renal pelvis and proximal ureter leading to severe hydronephrosis of the right kidney were diagnosed by abdominal ultrasound. A left adrenalectomy and right nephrectomy were performed and samples were submitted for histopathology, confirming the diagnosis of adrenocortical carcinoma and a transitional cell carcinoma of the ureter and renal pelvis. Increased sexual behavior resolved within 2 months following surgical resection of the affected left adrenal gland, but recurred 8 months later. The right adrenal gland had increased in size when compared to earlier ultrasonographic evalution. A 4.7-mg deslorelin implant was placed subcutaneously, which resulted in a decrease of testosteronemia and sexual behaviors for up to 18 months.

KW - adrenocortical carcinoma

KW - deslorelin

KW - GnRH agonist

KW - hypertestosteronism

KW - rabbit

KW - renal transitional cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=84994067229&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994067229&partnerID=8YFLogxK

U2 - 10.1053/j.jepm.2016.06.010

DO - 10.1053/j.jepm.2016.06.010

M3 - Article

AN - SCOPUS:84994067229

VL - 25

SP - 332

EP - 341

JO - Journal of Exotic Pet Medicine

JF - Journal of Exotic Pet Medicine

SN - 1557-5063

IS - 4

ER -