Adrenal hormones and the anorectic response and adaptation of rats to amino acid imbalance

V. A. Hammer, D. W. Gietzen, V. D. Sworts, J. L. Beverly, Quinton Rogers

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12 Scopus citations


The role of adrenal function in the anorectic response and adaptation of rats to a diet with an isoleucine (Ile) imbalance was investigated. In the first of four experiments, rats were fed a mildly Ile-imbalanced diet after treatment with metyrapone, an inhibitor of glucocorticoid synthesis. In two separate experiments, rats were presented with either a mildly or severely Ile-imbalanced diet (4.93 and 9.86% imbalanced amino acid mixture, respectively) after bilateral adrenalectomy. Finally, the effects of ICS 205-930, a serotonin-3 receptor antagonist, on the intake of mildly Ile-imbalanced diet were tested in adrenalectomized animals. In each experiment a 2 x 2 factorial design was used. Neither metyrapone nor adrenalectomy altered the initial depression in the intake of an imbalanced diet. The adaptation phase in the response of adrenalectomized rats fed a mildly Ile-imbalanced diet was not different from that of controls, but adrenalectomized rats fed severely Ile-imbalanced diets were unable to adapt. Adrenalectomy did not alter the anti-anoretic activity of ICS 205-930 in this model. These results suggest that adrenal hormones are not necessary for the initial anoretic response or adaptation of rats to an Ile-imbalanced diet, nor are they implicated in the anti-anorectic effect of serotonin-3 blockade.

Original languageEnglish (US)
Pages (from-to)1617-1623
Number of pages7
JournalJournal of Nutrition
Issue number12
StatePublished - Jan 1 1990


  • Adrenalectomy
  • Amino acid imbalance
  • Metyrapone
  • Rats
  • Serotonin antagonist

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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