Adolescent impatience decreases with increased frontostriatal connectivity

Wouter Van Den Bos, Christian A. Rodriguez, Julie B Schweitzer, Samuel M. McClure

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Adolescence is a developmental period associated with an increase in impulsivity. Impulsivity is a multidimensional construct, and in this study we focus on one of the underlying components: impatience. Impatience can result from (i) disregard of future outcomes and/or (ii) oversensitivity to immediate rewards, but it is not known which of these evaluative processes underlie developmental changes. To distinguish between these two causes, we investigated developmental changes in the structural and functional connectivity of different frontostriatal tracts. We report that adolescents were more impatient on an intertemporal choice task and reported less future orientation, but not more present hedonism, than young adults. Developmental increases in structural connectivity strength in the right dorsolateral prefrontal tract were related to increased negative functional coupling with the striatum and an age-related decrease in discount rates. Our results suggest that mainly increased control, and the integration of future-oriented thought, drives the reduction in impatience across adolescence.

Original languageEnglish (US)
Pages (from-to)E3765-E3774
JournalProceedings of the National Academy of Sciences of the United States of America
Volume112
Issue number29
DOIs
StatePublished - Jul 21 2015

Fingerprint

Impulsive Behavior
Reward
Young Adult
Drive

Keywords

  • Adolescence
  • Connectivity
  • Delay discounting
  • DTI
  • Impatience

ASJC Scopus subject areas

  • General

Cite this

Adolescent impatience decreases with increased frontostriatal connectivity. / Van Den Bos, Wouter; Rodriguez, Christian A.; Schweitzer, Julie B; McClure, Samuel M.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, No. 29, 21.07.2015, p. E3765-E3774.

Research output: Contribution to journalArticle

Van Den Bos, Wouter ; Rodriguez, Christian A. ; Schweitzer, Julie B ; McClure, Samuel M. / Adolescent impatience decreases with increased frontostriatal connectivity. In: Proceedings of the National Academy of Sciences of the United States of America. 2015 ; Vol. 112, No. 29. pp. E3765-E3774.
@article{d3a1a52324984bc3994349abee01424b,
title = "Adolescent impatience decreases with increased frontostriatal connectivity",
abstract = "Adolescence is a developmental period associated with an increase in impulsivity. Impulsivity is a multidimensional construct, and in this study we focus on one of the underlying components: impatience. Impatience can result from (i) disregard of future outcomes and/or (ii) oversensitivity to immediate rewards, but it is not known which of these evaluative processes underlie developmental changes. To distinguish between these two causes, we investigated developmental changes in the structural and functional connectivity of different frontostriatal tracts. We report that adolescents were more impatient on an intertemporal choice task and reported less future orientation, but not more present hedonism, than young adults. Developmental increases in structural connectivity strength in the right dorsolateral prefrontal tract were related to increased negative functional coupling with the striatum and an age-related decrease in discount rates. Our results suggest that mainly increased control, and the integration of future-oriented thought, drives the reduction in impatience across adolescence.",
keywords = "Adolescence, Connectivity, Delay discounting, DTI, Impatience",
author = "{Van Den Bos}, Wouter and Rodriguez, {Christian A.} and Schweitzer, {Julie B} and McClure, {Samuel M.}",
year = "2015",
month = "7",
day = "21",
doi = "10.1073/pnas.1423095112",
language = "English (US)",
volume = "112",
pages = "E3765--E3774",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "29",

}

TY - JOUR

T1 - Adolescent impatience decreases with increased frontostriatal connectivity

AU - Van Den Bos, Wouter

AU - Rodriguez, Christian A.

AU - Schweitzer, Julie B

AU - McClure, Samuel M.

PY - 2015/7/21

Y1 - 2015/7/21

N2 - Adolescence is a developmental period associated with an increase in impulsivity. Impulsivity is a multidimensional construct, and in this study we focus on one of the underlying components: impatience. Impatience can result from (i) disregard of future outcomes and/or (ii) oversensitivity to immediate rewards, but it is not known which of these evaluative processes underlie developmental changes. To distinguish between these two causes, we investigated developmental changes in the structural and functional connectivity of different frontostriatal tracts. We report that adolescents were more impatient on an intertemporal choice task and reported less future orientation, but not more present hedonism, than young adults. Developmental increases in structural connectivity strength in the right dorsolateral prefrontal tract were related to increased negative functional coupling with the striatum and an age-related decrease in discount rates. Our results suggest that mainly increased control, and the integration of future-oriented thought, drives the reduction in impatience across adolescence.

AB - Adolescence is a developmental period associated with an increase in impulsivity. Impulsivity is a multidimensional construct, and in this study we focus on one of the underlying components: impatience. Impatience can result from (i) disregard of future outcomes and/or (ii) oversensitivity to immediate rewards, but it is not known which of these evaluative processes underlie developmental changes. To distinguish between these two causes, we investigated developmental changes in the structural and functional connectivity of different frontostriatal tracts. We report that adolescents were more impatient on an intertemporal choice task and reported less future orientation, but not more present hedonism, than young adults. Developmental increases in structural connectivity strength in the right dorsolateral prefrontal tract were related to increased negative functional coupling with the striatum and an age-related decrease in discount rates. Our results suggest that mainly increased control, and the integration of future-oriented thought, drives the reduction in impatience across adolescence.

KW - Adolescence

KW - Connectivity

KW - Delay discounting

KW - DTI

KW - Impatience

UR - http://www.scopus.com/inward/record.url?scp=84937501624&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937501624&partnerID=8YFLogxK

U2 - 10.1073/pnas.1423095112

DO - 10.1073/pnas.1423095112

M3 - Article

VL - 112

SP - E3765-E3774

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 29

ER -