Abstract
Growth retardation has been associated with zinc deficiency in adolescent human populations, but animal models were not available previously to explore this syndrome. Moderate dietary zinc deprivation (2 μg Zn/g diet) was introduced in female rhesus monkeys (Macaca mulatta; n = 10) from the beginning of puberty through menarche. Subgroups of animals (n = 4) continued to be fed the zinc deficient diet through 45 mo of age (sexual maturity). Reduced weight gain and linear growth and lower plasma zinc concentrations (11.8 ± 0.6 and 9.2 ± 0.8 μmol/L in control and zincdeficient monkeys, respectively) were evident during the premenarcheal growth spurt. Slower skeletal growth, maturation, and mineralization were recorded in the postmenarcheal period and some indicators of sexual maturation were delayed. Food intake was slightly higher in the zinc-deficient group than in controls. These data confirm that adolescent growth and maturation are vulnerable to disruption by moderate dietary zinc deprivation in nonhuman primates.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 274-282 |
| Number of pages | 9 |
| Journal | American Journal of Clinical Nutrition |
| Volume | 64 |
| Issue number | 3 |
| State | Published - Sep 1996 |
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Keywords
- adolescence
- bone mineralization
- diet
- female rhesus monkeys
- puberty
- skeletal maturation
- Zinc deficiency
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Food Science
Cite this
Adolescent growth and maturation in zinc-deprived rhesus monkeys. / Golub, Mari S.; Keen, Carl L; Gershwin, M. Eric; Styne, Dennis M; Takeuchi, Peter T.; Ontell, Francesca; Walter, Robert M.; Hendrickx, Andrew G.
In: American Journal of Clinical Nutrition, Vol. 64, No. 3, 09.1996, p. 274-282.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adolescent growth and maturation in zinc-deprived rhesus monkeys
AU - Golub, Mari S.
AU - Keen, Carl L
AU - Gershwin, M. Eric
AU - Styne, Dennis M
AU - Takeuchi, Peter T.
AU - Ontell, Francesca
AU - Walter, Robert M.
AU - Hendrickx, Andrew G
PY - 1996/9
Y1 - 1996/9
N2 - Growth retardation has been associated with zinc deficiency in adolescent human populations, but animal models were not available previously to explore this syndrome. Moderate dietary zinc deprivation (2 μg Zn/g diet) was introduced in female rhesus monkeys (Macaca mulatta; n = 10) from the beginning of puberty through menarche. Subgroups of animals (n = 4) continued to be fed the zinc deficient diet through 45 mo of age (sexual maturity). Reduced weight gain and linear growth and lower plasma zinc concentrations (11.8 ± 0.6 and 9.2 ± 0.8 μmol/L in control and zincdeficient monkeys, respectively) were evident during the premenarcheal growth spurt. Slower skeletal growth, maturation, and mineralization were recorded in the postmenarcheal period and some indicators of sexual maturation were delayed. Food intake was slightly higher in the zinc-deficient group than in controls. These data confirm that adolescent growth and maturation are vulnerable to disruption by moderate dietary zinc deprivation in nonhuman primates.
AB - Growth retardation has been associated with zinc deficiency in adolescent human populations, but animal models were not available previously to explore this syndrome. Moderate dietary zinc deprivation (2 μg Zn/g diet) was introduced in female rhesus monkeys (Macaca mulatta; n = 10) from the beginning of puberty through menarche. Subgroups of animals (n = 4) continued to be fed the zinc deficient diet through 45 mo of age (sexual maturity). Reduced weight gain and linear growth and lower plasma zinc concentrations (11.8 ± 0.6 and 9.2 ± 0.8 μmol/L in control and zincdeficient monkeys, respectively) were evident during the premenarcheal growth spurt. Slower skeletal growth, maturation, and mineralization were recorded in the postmenarcheal period and some indicators of sexual maturation were delayed. Food intake was slightly higher in the zinc-deficient group than in controls. These data confirm that adolescent growth and maturation are vulnerable to disruption by moderate dietary zinc deprivation in nonhuman primates.
KW - adolescence
KW - bone mineralization
KW - diet
KW - female rhesus monkeys
KW - puberty
KW - skeletal maturation
KW - Zinc deficiency
UR - http://www.scopus.com/inward/record.url?scp=0029822341&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029822341&partnerID=8YFLogxK
M3 - Article
C2 - 8780334
AN - SCOPUS:0029822341
VL - 64
SP - 274
EP - 282
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 3
ER -