Admixture mapping as a tool in gene discovery

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Admixture mapping is a rapidly developing method to map susceptibility alleles in complex genetic disease associated with continental ancestry. Theoretically, when admixture between continental populations has occurred relatively recently, the chromosomal segments derived from the parental populations can be deduced from the differences in genotype allele frequencies. Progress in computational algorithms, in identification of ancestry informative single nucleotide polymorphisms, and in recent studies applying these tools suggests that this approach will complement other strategies for identifying the variation that underlies many complex diseases.

Original languageEnglish (US)
Pages (from-to)177-181
Number of pages5
JournalCurrent Opinion in Genetics and Development
Volume17
Issue number3
DOIs
StatePublished - Jun 2007

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Genetic Association Studies
Inborn Genetic Diseases
Gene Frequency
Population
Single Nucleotide Polymorphism
Alleles
Genotype

ASJC Scopus subject areas

  • Genetics

Cite this

Admixture mapping as a tool in gene discovery. / Seldin, Michael F.

In: Current Opinion in Genetics and Development, Vol. 17, No. 3, 06.2007, p. 177-181.

Research output: Contribution to journalArticle

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