Admission Temperature and Associated Mortality and Morbidity among Moderately and Extremely Preterm Infants

Generic and Moderate Preterm Subcommittees of the NICHD Neonatal Research Network

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective To evaluate the temperature distribution among moderately preterm (MPT, 29-33 weeks) and extremely preterm (EPT, <29 weeks) infants upon neonatal intensive care unit (NICU) admission in 2012-2013, the change in admission temperature distribution for EPT infants between 2002-2003 and 2012-2013, and associations between admission temperature and mortality and morbidity for both MPT and EPT infants. Study design Prospectively collected data from 18 centers in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network were used to examine NICU admission temperature of inborn MPT and EPT infants. Associations between admission temperature and mortality and morbidity were determined by multivariable logistic regression. EPT infants from 2002-2003 and 2012-2013 were compared. Results MPT and EPT cohorts consisted of 5818 and 3213 infants, respectively. The distribution of admission temperatures differed between the MPT vs EPT (P <.01), including the percentage <36.5°C (38.6% vs 40.9%), 36.5°C-37.5°C (57.3% vs 52.9%), and >37.5°C (4.2% vs 6.2%). For EPT infants in 2012-2013 compared with 2002-2003, the percentage of temperatures between 36.5°C and 37.5°C more than doubled and the percentage of temperatures >37.5°C more than tripled. Admission temperature was inversely associated with in-hospital mortality. Conclusions Low and high admission temperatures are more frequent among EPT than MPT infants. Compared with a decade earlier, fewer EPT infants experience low admission temperatures but more have elevated temperatures. In spite of a change in distribution of NICU admission temperature, an inverse association between temperature and mortality risk persists.

Original languageEnglish (US)
Pages (from-to)53-59.e2
JournalJournal of Pediatrics
Volume192
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Fingerprint

Extremely Premature Infants
Morbidity
Temperature
Mortality
Hospital Mortality

Keywords

  • hyperthermia
  • hypothermia
  • prematurity
  • survival

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Admission Temperature and Associated Mortality and Morbidity among Moderately and Extremely Preterm Infants. / Generic and Moderate Preterm Subcommittees of the NICHD Neonatal Research Network.

In: Journal of Pediatrics, Vol. 192, 01.01.2018, p. 53-59.e2.

Research output: Contribution to journalArticle

Generic and Moderate Preterm Subcommittees of the NICHD Neonatal Research Network 2018, 'Admission Temperature and Associated Mortality and Morbidity among Moderately and Extremely Preterm Infants', Journal of Pediatrics, vol. 192, pp. 53-59.e2. https://doi.org/10.1016/j.jpeds.2017.09.021
Generic and Moderate Preterm Subcommittees of the NICHD Neonatal Research Network. / Admission Temperature and Associated Mortality and Morbidity among Moderately and Extremely Preterm Infants. In: Journal of Pediatrics. 2018 ; Vol. 192. pp. 53-59.e2.
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title = "Admission Temperature and Associated Mortality and Morbidity among Moderately and Extremely Preterm Infants",
abstract = "Objective To evaluate the temperature distribution among moderately preterm (MPT, 29-33 weeks) and extremely preterm (EPT, <29 weeks) infants upon neonatal intensive care unit (NICU) admission in 2012-2013, the change in admission temperature distribution for EPT infants between 2002-2003 and 2012-2013, and associations between admission temperature and mortality and morbidity for both MPT and EPT infants. Study design Prospectively collected data from 18 centers in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network were used to examine NICU admission temperature of inborn MPT and EPT infants. Associations between admission temperature and mortality and morbidity were determined by multivariable logistic regression. EPT infants from 2002-2003 and 2012-2013 were compared. Results MPT and EPT cohorts consisted of 5818 and 3213 infants, respectively. The distribution of admission temperatures differed between the MPT vs EPT (P <.01), including the percentage <36.5°C (38.6{\%} vs 40.9{\%}), 36.5°C-37.5°C (57.3{\%} vs 52.9{\%}), and >37.5°C (4.2{\%} vs 6.2{\%}). For EPT infants in 2012-2013 compared with 2002-2003, the percentage of temperatures between 36.5°C and 37.5°C more than doubled and the percentage of temperatures >37.5°C more than tripled. Admission temperature was inversely associated with in-hospital mortality. Conclusions Low and high admission temperatures are more frequent among EPT than MPT infants. Compared with a decade earlier, fewer EPT infants experience low admission temperatures but more have elevated temperatures. In spite of a change in distribution of NICU admission temperature, an inverse association between temperature and mortality risk persists.",
keywords = "hyperthermia, hypothermia, prematurity, survival",
author = "{Generic and Moderate Preterm Subcommittees of the NICHD Neonatal Research Network} and Laptook, {Abbot R.} and Bell, {Edward F.} and Seetha Shankaran and Boghossian, {Nansi S.} and Wyckoff, {Myra H.} and Sarah Kandefer and Michele Walsh and Shampa Saha and Rosemary Higgins and Polin, {Richard A.} and Martin Keszler and Vohr, {Betty R.} and Hensman, {Angelita M.} and Elisa Vieira and Emilee Little and Fanaroff, {Avroy A.} and Hibbs, {Anna Marie} and Newman, {Nancy S.} and Siner, {Bonnie S.} and Truog, {William E.} and Pallotto, {Eugenia K.} and Kilbride, {Howard W.} and Cheri Gauldin and Anne Holmes and Kathy Johnson and Kurt Schibler and Kallapur, {Suhas G.} and Cathy Grisby and Barbara Alexander and Fischer, {Estelle E.} and Lenora Jackson and Kristin Kirker and Jennifer Jennings and Sandra Wuertz and Greg Muthig and Donovan, {Edward F.} and Jody Hessling and Mersmann, {Marcia Worley} and Mincey, {Holly L.} and Cotten, {C. Michael} and Goldberg, {Ronald N.} and Joanne Finkle and Fisher, {Kimberley A.} and Auten, {Kathy J.} and Laughon, {Matthew M.} and Bose, {Carl L.} and Janice Bernhardt and Cindy Clark and Stoll, {Barbara J.} and Satyanarayana Lakshminrusimha",
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TY - JOUR

T1 - Admission Temperature and Associated Mortality and Morbidity among Moderately and Extremely Preterm Infants

AU - Generic and Moderate Preterm Subcommittees of the NICHD Neonatal Research Network

AU - Laptook, Abbot R.

AU - Bell, Edward F.

AU - Shankaran, Seetha

AU - Boghossian, Nansi S.

AU - Wyckoff, Myra H.

AU - Kandefer, Sarah

AU - Walsh, Michele

AU - Saha, Shampa

AU - Higgins, Rosemary

AU - Polin, Richard A.

AU - Keszler, Martin

AU - Vohr, Betty R.

AU - Hensman, Angelita M.

AU - Vieira, Elisa

AU - Little, Emilee

AU - Fanaroff, Avroy A.

AU - Hibbs, Anna Marie

AU - Newman, Nancy S.

AU - Siner, Bonnie S.

AU - Truog, William E.

AU - Pallotto, Eugenia K.

AU - Kilbride, Howard W.

AU - Gauldin, Cheri

AU - Holmes, Anne

AU - Johnson, Kathy

AU - Schibler, Kurt

AU - Kallapur, Suhas G.

AU - Grisby, Cathy

AU - Alexander, Barbara

AU - Fischer, Estelle E.

AU - Jackson, Lenora

AU - Kirker, Kristin

AU - Jennings, Jennifer

AU - Wuertz, Sandra

AU - Muthig, Greg

AU - Donovan, Edward F.

AU - Hessling, Jody

AU - Mersmann, Marcia Worley

AU - Mincey, Holly L.

AU - Cotten, C. Michael

AU - Goldberg, Ronald N.

AU - Finkle, Joanne

AU - Fisher, Kimberley A.

AU - Auten, Kathy J.

AU - Laughon, Matthew M.

AU - Bose, Carl L.

AU - Bernhardt, Janice

AU - Clark, Cindy

AU - Stoll, Barbara J.

AU - Lakshminrusimha, Satyanarayana

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objective To evaluate the temperature distribution among moderately preterm (MPT, 29-33 weeks) and extremely preterm (EPT, <29 weeks) infants upon neonatal intensive care unit (NICU) admission in 2012-2013, the change in admission temperature distribution for EPT infants between 2002-2003 and 2012-2013, and associations between admission temperature and mortality and morbidity for both MPT and EPT infants. Study design Prospectively collected data from 18 centers in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network were used to examine NICU admission temperature of inborn MPT and EPT infants. Associations between admission temperature and mortality and morbidity were determined by multivariable logistic regression. EPT infants from 2002-2003 and 2012-2013 were compared. Results MPT and EPT cohorts consisted of 5818 and 3213 infants, respectively. The distribution of admission temperatures differed between the MPT vs EPT (P <.01), including the percentage <36.5°C (38.6% vs 40.9%), 36.5°C-37.5°C (57.3% vs 52.9%), and >37.5°C (4.2% vs 6.2%). For EPT infants in 2012-2013 compared with 2002-2003, the percentage of temperatures between 36.5°C and 37.5°C more than doubled and the percentage of temperatures >37.5°C more than tripled. Admission temperature was inversely associated with in-hospital mortality. Conclusions Low and high admission temperatures are more frequent among EPT than MPT infants. Compared with a decade earlier, fewer EPT infants experience low admission temperatures but more have elevated temperatures. In spite of a change in distribution of NICU admission temperature, an inverse association between temperature and mortality risk persists.

AB - Objective To evaluate the temperature distribution among moderately preterm (MPT, 29-33 weeks) and extremely preterm (EPT, <29 weeks) infants upon neonatal intensive care unit (NICU) admission in 2012-2013, the change in admission temperature distribution for EPT infants between 2002-2003 and 2012-2013, and associations between admission temperature and mortality and morbidity for both MPT and EPT infants. Study design Prospectively collected data from 18 centers in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network were used to examine NICU admission temperature of inborn MPT and EPT infants. Associations between admission temperature and mortality and morbidity were determined by multivariable logistic regression. EPT infants from 2002-2003 and 2012-2013 were compared. Results MPT and EPT cohorts consisted of 5818 and 3213 infants, respectively. The distribution of admission temperatures differed between the MPT vs EPT (P <.01), including the percentage <36.5°C (38.6% vs 40.9%), 36.5°C-37.5°C (57.3% vs 52.9%), and >37.5°C (4.2% vs 6.2%). For EPT infants in 2012-2013 compared with 2002-2003, the percentage of temperatures between 36.5°C and 37.5°C more than doubled and the percentage of temperatures >37.5°C more than tripled. Admission temperature was inversely associated with in-hospital mortality. Conclusions Low and high admission temperatures are more frequent among EPT than MPT infants. Compared with a decade earlier, fewer EPT infants experience low admission temperatures but more have elevated temperatures. In spite of a change in distribution of NICU admission temperature, an inverse association between temperature and mortality risk persists.

KW - hyperthermia

KW - hypothermia

KW - prematurity

KW - survival

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