Administration of recombinant granulocyte colony-stimulating factor to neonates with septicemia: A meta-analysis

Hilton M. Bernstein, Bradley H Pollock, Darlene A. Calhoun, Robert D. Christensen

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

A meta-analysis was used to determine whether administering recombinant granulocyte colony-stimulating factor (rG-CSF) to neonates with bacterial septicemia reduces mortality. Five studies were identified, involving 73 rG-CSF recipients and 82 control subjects. Mortality was lower among the rG-CSF recipients (odds ratio, 0.17; CI, 0.03-0.70; P < .05). However, when the non-randomized studies were excluded, the P value was .13. For the subgroups "<2000 g" or "neutropenia," the P value was <.02. Thus the routine use of rG-CSF cannot be recommended for all neonates with sepsis.

Original languageEnglish (US)
Pages (from-to)917-920
Number of pages4
JournalJournal of Pediatrics
Volume138
Issue number6
DOIs
StatePublished - 2001
Externally publishedYes

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Granulocyte Colony-Stimulating Factor
Meta-Analysis
Sepsis
Mortality
Neutropenia
Odds Ratio

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Administration of recombinant granulocyte colony-stimulating factor to neonates with septicemia : A meta-analysis. / Bernstein, Hilton M.; Pollock, Bradley H; Calhoun, Darlene A.; Christensen, Robert D.

In: Journal of Pediatrics, Vol. 138, No. 6, 2001, p. 917-920.

Research output: Contribution to journalArticle

Bernstein, Hilton M. ; Pollock, Bradley H ; Calhoun, Darlene A. ; Christensen, Robert D. / Administration of recombinant granulocyte colony-stimulating factor to neonates with septicemia : A meta-analysis. In: Journal of Pediatrics. 2001 ; Vol. 138, No. 6. pp. 917-920.
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