Administration of recombinant granulocyte colony-stimulating factor to neonates with septicemia: A meta-analysis

Hilton M. Bernstein, Bradley H Pollock, Darlene A. Calhoun, Robert D. Christensen

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

A meta-analysis was used to determine whether administering recombinant granulocyte colony-stimulating factor (rG-CSF) to neonates with bacterial septicemia reduces mortality. Five studies were identified, involving 73 rG-CSF recipients and 82 control subjects. Mortality was lower among the rG-CSF recipients (odds ratio, 0.17; CI, 0.03-0.70; P < .05). However, when the non-randomized studies were excluded, the P value was .13. For the subgroups "<2000 g" or "neutropenia," the P value was <.02. Thus the routine use of rG-CSF cannot be recommended for all neonates with sepsis.

Original languageEnglish (US)
Pages (from-to)917-920
Number of pages4
JournalJournal of Pediatrics
Volume138
Issue number6
DOIs
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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