Adjuvant therapy of ovarian cancer with radioactive monoclonal antibody

V. Hird, A. Maraveyas, D. Snook, B. Dhokia, W. P. Soutter, C. Meares, J. S W Stewart, P. Mason, H. E. Lambert, A. A. Epenetos

Research output: Contribution to journalArticlepeer-review

159 Scopus citations


Fifty-two patients with epithelial ovarian cancer were treated with yttrium-90-labelled monoclonal antibody HMFG1 administered intraperitoneally following conventional surgery and chemotherapy as part of an extended phase I-II trial. The treatment was well tolerated and the only significant toxicity observed was reversible myelosuppression as previously described. Following conventional surgery and chemotherapy, 21 out of the 52 patients had no evidence of residual disease and were regarded as receiving treatment in an adjuvant setting. To date, two of these patients have died of their disease (follow-up 3-62 months, median follow-up 35 months). This extended phase I-11 study suggests that patients with advanced ovarian cancer who achieve a complete remission following conventional therapy may benefit from further treatment with intraperitoneal radioactive monoclonal antibody.

Original languageEnglish (US)
Pages (from-to)403-406
Number of pages4
JournalBritish Journal of Cancer
Issue number2
StatePublished - Aug 1993

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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