Adjuvant radiation therapy is associated with improved survival for adenoid cystic carcinoma of the breast

Jodi M. Coates, Steve R. Martinez, Richard J Bold, Steven L. Chen

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: The role of adjuvant radiation therapy (RT) for adenoid cystic carcinoma (ACC) of the breast remains unclear. Materials and Methods: We queried the Surveillance, Epidemiology, and End Results database for patients with breast ACC resected between 1988 and 2005, and divided patients based on the receipt of RT. Univariate and multivariate survival comparisons were made for overall and disease-specific survival. Results: Three hundred seventy six patients met criteria for inclusion. Demographics and staging were similar between groups. Univariate analysis revealed an absolute overall and cause-specific survival benefit of 21% and 7% at 10 years (P = 0.005 and P = 0.12 respectively). In the multivariate analysis, RT was a significant predictor of overall and cause-specific survival with hazard ratios of 0.44 (95% Confidence interval (CI) = 0.22-0.88) and 0.1 (95% CI: 0.01-0.88), respectively. Conclusions: RTafter local surgical therapy for ACC of the breast improved both cause-specific and overall survival. Use of RT in this rare tumor should be considered in patients otherwise eligible for RT.

Original languageEnglish (US)
Pages (from-to)342-347
Number of pages6
JournalJournal of Surgical Oncology
Volume102
Issue number4
DOIs
StatePublished - Sep 15 2010

Fingerprint

Adenoid Cystic Carcinoma
Breast
Radiotherapy
Survival
Confidence Intervals
Epidemiology
Multivariate Analysis
Demography
Databases
Neoplasms

Keywords

  • Adenoid cystic carcinoma
  • Adjuvant therapy
  • Breast cancer
  • Radiation therapy
  • Survival

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Adjuvant radiation therapy is associated with improved survival for adenoid cystic carcinoma of the breast. / Coates, Jodi M.; Martinez, Steve R.; Bold, Richard J; Chen, Steven L.

In: Journal of Surgical Oncology, Vol. 102, No. 4, 15.09.2010, p. 342-347.

Research output: Contribution to journalArticle

@article{678cb27bd2da4afbb2e9474a80cfe1ff,
title = "Adjuvant radiation therapy is associated with improved survival for adenoid cystic carcinoma of the breast",
abstract = "Background: The role of adjuvant radiation therapy (RT) for adenoid cystic carcinoma (ACC) of the breast remains unclear. Materials and Methods: We queried the Surveillance, Epidemiology, and End Results database for patients with breast ACC resected between 1988 and 2005, and divided patients based on the receipt of RT. Univariate and multivariate survival comparisons were made for overall and disease-specific survival. Results: Three hundred seventy six patients met criteria for inclusion. Demographics and staging were similar between groups. Univariate analysis revealed an absolute overall and cause-specific survival benefit of 21{\%} and 7{\%} at 10 years (P = 0.005 and P = 0.12 respectively). In the multivariate analysis, RT was a significant predictor of overall and cause-specific survival with hazard ratios of 0.44 (95{\%} Confidence interval (CI) = 0.22-0.88) and 0.1 (95{\%} CI: 0.01-0.88), respectively. Conclusions: RTafter local surgical therapy for ACC of the breast improved both cause-specific and overall survival. Use of RT in this rare tumor should be considered in patients otherwise eligible for RT.",
keywords = "Adenoid cystic carcinoma, Adjuvant therapy, Breast cancer, Radiation therapy, Survival",
author = "Coates, {Jodi M.} and Martinez, {Steve R.} and Bold, {Richard J} and Chen, {Steven L.}",
year = "2010",
month = "9",
day = "15",
doi = "10.1002/jso.21638",
language = "English (US)",
volume = "102",
pages = "342--347",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Adjuvant radiation therapy is associated with improved survival for adenoid cystic carcinoma of the breast

AU - Coates, Jodi M.

AU - Martinez, Steve R.

AU - Bold, Richard J

AU - Chen, Steven L.

PY - 2010/9/15

Y1 - 2010/9/15

N2 - Background: The role of adjuvant radiation therapy (RT) for adenoid cystic carcinoma (ACC) of the breast remains unclear. Materials and Methods: We queried the Surveillance, Epidemiology, and End Results database for patients with breast ACC resected between 1988 and 2005, and divided patients based on the receipt of RT. Univariate and multivariate survival comparisons were made for overall and disease-specific survival. Results: Three hundred seventy six patients met criteria for inclusion. Demographics and staging were similar between groups. Univariate analysis revealed an absolute overall and cause-specific survival benefit of 21% and 7% at 10 years (P = 0.005 and P = 0.12 respectively). In the multivariate analysis, RT was a significant predictor of overall and cause-specific survival with hazard ratios of 0.44 (95% Confidence interval (CI) = 0.22-0.88) and 0.1 (95% CI: 0.01-0.88), respectively. Conclusions: RTafter local surgical therapy for ACC of the breast improved both cause-specific and overall survival. Use of RT in this rare tumor should be considered in patients otherwise eligible for RT.

AB - Background: The role of adjuvant radiation therapy (RT) for adenoid cystic carcinoma (ACC) of the breast remains unclear. Materials and Methods: We queried the Surveillance, Epidemiology, and End Results database for patients with breast ACC resected between 1988 and 2005, and divided patients based on the receipt of RT. Univariate and multivariate survival comparisons were made for overall and disease-specific survival. Results: Three hundred seventy six patients met criteria for inclusion. Demographics and staging were similar between groups. Univariate analysis revealed an absolute overall and cause-specific survival benefit of 21% and 7% at 10 years (P = 0.005 and P = 0.12 respectively). In the multivariate analysis, RT was a significant predictor of overall and cause-specific survival with hazard ratios of 0.44 (95% Confidence interval (CI) = 0.22-0.88) and 0.1 (95% CI: 0.01-0.88), respectively. Conclusions: RTafter local surgical therapy for ACC of the breast improved both cause-specific and overall survival. Use of RT in this rare tumor should be considered in patients otherwise eligible for RT.

KW - Adenoid cystic carcinoma

KW - Adjuvant therapy

KW - Breast cancer

KW - Radiation therapy

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=77956598237&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956598237&partnerID=8YFLogxK

U2 - 10.1002/jso.21638

DO - 10.1002/jso.21638

M3 - Article

C2 - 20589709

AN - SCOPUS:77956598237

VL - 102

SP - 342

EP - 347

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 4

ER -