Adjuvant radiation therapy is associated with improved survival for adenoid cystic carcinoma of the breast

Jodi M. Coates, Steve R. Martinez, Richard J Bold, Steven L. Chen

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Background: The role of adjuvant radiation therapy (RT) for adenoid cystic carcinoma (ACC) of the breast remains unclear. Materials and Methods: We queried the Surveillance, Epidemiology, and End Results database for patients with breast ACC resected between 1988 and 2005, and divided patients based on the receipt of RT. Univariate and multivariate survival comparisons were made for overall and disease-specific survival. Results: Three hundred seventy six patients met criteria for inclusion. Demographics and staging were similar between groups. Univariate analysis revealed an absolute overall and cause-specific survival benefit of 21% and 7% at 10 years (P = 0.005 and P = 0.12 respectively). In the multivariate analysis, RT was a significant predictor of overall and cause-specific survival with hazard ratios of 0.44 (95% Confidence interval (CI) = 0.22-0.88) and 0.1 (95% CI: 0.01-0.88), respectively. Conclusions: RTafter local surgical therapy for ACC of the breast improved both cause-specific and overall survival. Use of RT in this rare tumor should be considered in patients otherwise eligible for RT.

Original languageEnglish (US)
Pages (from-to)342-347
Number of pages6
JournalJournal of Surgical Oncology
Issue number4
StatePublished - Sep 15 2010


  • Adenoid cystic carcinoma
  • Adjuvant therapy
  • Breast cancer
  • Radiation therapy
  • Survival

ASJC Scopus subject areas

  • Surgery
  • Oncology


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