Adjuvant external beam radiation for medullary thyroid carcinoma

Steve R. Martinez, Shannon H. Beal, Allen Chen, Steven L. Chen, Philip D Schneider

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background: Adjuvant radiation is rarely used to treat medullary thyroid carcinoma (MTC). We hypothesized that external beam radiation therapy (EBRT) would improve overall survival (OS) in MTC patients. Methods: The Surveillance, Epidemiology, and End Results (SEER) database identified patients who underwent total thyroidectomy and lymph nodes excision for MTC between 1988 and 2004. The Kaplan-Meier method was used for univariate comparisons of OS. Multivariate Cox proportional hazards models controlled for gender, age, lymph node status, tumor size, extent of disease, and EBRT. Results: After 12 years, EBRT did not significantly improve OS (log rank, P < 0.14). In node-positive patients, univariate analysis demonstrated an OS benefit with EBRT (log rank, P < 0.05). In a multivariate model of node-positive patients, only increasing age (P < 0.001) and tumor size (P < 0.001) significantly influenced OS. Conclusions: The OS benefit attributed to EBRT in node-positive patients by univariate analysis could not be duplicated when controlling for known prognostic factors.

Original languageEnglish (US)
Pages (from-to)175-178
Number of pages4
JournalJournal of Surgical Oncology
Volume102
Issue number2
DOIs
StatePublished - Aug 1 2010

Fingerprint

Radiation
Radiotherapy
Survival
Background Radiation
Thyroidectomy
Lymph Node Excision
Proportional Hazards Models
Medullary Thyroid cancer
Neoplasms
Epidemiology
Lymph Nodes
Databases

Keywords

  • Medullary thyroid carcinoma
  • Radiation
  • Survival

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Adjuvant external beam radiation for medullary thyroid carcinoma. / Martinez, Steve R.; Beal, Shannon H.; Chen, Allen; Chen, Steven L.; Schneider, Philip D.

In: Journal of Surgical Oncology, Vol. 102, No. 2, 01.08.2010, p. 175-178.

Research output: Contribution to journalArticle

Martinez, Steve R. ; Beal, Shannon H. ; Chen, Allen ; Chen, Steven L. ; Schneider, Philip D. / Adjuvant external beam radiation for medullary thyroid carcinoma. In: Journal of Surgical Oncology. 2010 ; Vol. 102, No. 2. pp. 175-178.
@article{f4699fb5ca994f7e80210f493e942d42,
title = "Adjuvant external beam radiation for medullary thyroid carcinoma",
abstract = "Background: Adjuvant radiation is rarely used to treat medullary thyroid carcinoma (MTC). We hypothesized that external beam radiation therapy (EBRT) would improve overall survival (OS) in MTC patients. Methods: The Surveillance, Epidemiology, and End Results (SEER) database identified patients who underwent total thyroidectomy and lymph nodes excision for MTC between 1988 and 2004. The Kaplan-Meier method was used for univariate comparisons of OS. Multivariate Cox proportional hazards models controlled for gender, age, lymph node status, tumor size, extent of disease, and EBRT. Results: After 12 years, EBRT did not significantly improve OS (log rank, P < 0.14). In node-positive patients, univariate analysis demonstrated an OS benefit with EBRT (log rank, P < 0.05). In a multivariate model of node-positive patients, only increasing age (P < 0.001) and tumor size (P < 0.001) significantly influenced OS. Conclusions: The OS benefit attributed to EBRT in node-positive patients by univariate analysis could not be duplicated when controlling for known prognostic factors.",
keywords = "Medullary thyroid carcinoma, Radiation, Survival",
author = "Martinez, {Steve R.} and Beal, {Shannon H.} and Allen Chen and Chen, {Steven L.} and Schneider, {Philip D}",
year = "2010",
month = "8",
day = "1",
doi = "10.1002/jso.21557",
language = "English (US)",
volume = "102",
pages = "175--178",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Adjuvant external beam radiation for medullary thyroid carcinoma

AU - Martinez, Steve R.

AU - Beal, Shannon H.

AU - Chen, Allen

AU - Chen, Steven L.

AU - Schneider, Philip D

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Background: Adjuvant radiation is rarely used to treat medullary thyroid carcinoma (MTC). We hypothesized that external beam radiation therapy (EBRT) would improve overall survival (OS) in MTC patients. Methods: The Surveillance, Epidemiology, and End Results (SEER) database identified patients who underwent total thyroidectomy and lymph nodes excision for MTC between 1988 and 2004. The Kaplan-Meier method was used for univariate comparisons of OS. Multivariate Cox proportional hazards models controlled for gender, age, lymph node status, tumor size, extent of disease, and EBRT. Results: After 12 years, EBRT did not significantly improve OS (log rank, P < 0.14). In node-positive patients, univariate analysis demonstrated an OS benefit with EBRT (log rank, P < 0.05). In a multivariate model of node-positive patients, only increasing age (P < 0.001) and tumor size (P < 0.001) significantly influenced OS. Conclusions: The OS benefit attributed to EBRT in node-positive patients by univariate analysis could not be duplicated when controlling for known prognostic factors.

AB - Background: Adjuvant radiation is rarely used to treat medullary thyroid carcinoma (MTC). We hypothesized that external beam radiation therapy (EBRT) would improve overall survival (OS) in MTC patients. Methods: The Surveillance, Epidemiology, and End Results (SEER) database identified patients who underwent total thyroidectomy and lymph nodes excision for MTC between 1988 and 2004. The Kaplan-Meier method was used for univariate comparisons of OS. Multivariate Cox proportional hazards models controlled for gender, age, lymph node status, tumor size, extent of disease, and EBRT. Results: After 12 years, EBRT did not significantly improve OS (log rank, P < 0.14). In node-positive patients, univariate analysis demonstrated an OS benefit with EBRT (log rank, P < 0.05). In a multivariate model of node-positive patients, only increasing age (P < 0.001) and tumor size (P < 0.001) significantly influenced OS. Conclusions: The OS benefit attributed to EBRT in node-positive patients by univariate analysis could not be duplicated when controlling for known prognostic factors.

KW - Medullary thyroid carcinoma

KW - Radiation

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=77955111802&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955111802&partnerID=8YFLogxK

U2 - 10.1002/jso.21557

DO - 10.1002/jso.21557

M3 - Article

C2 - 20648590

AN - SCOPUS:77955111802

VL - 102

SP - 175

EP - 178

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 2

ER -