Adjuvant and salvage radiation therapy after prostatectomy: American society for radiation oncology/american urological association guidelines

Richard K Valicenti, Ian Thompson, Peter Albertsen, Brian J. Davis, S. Larry Goldenberg, J. Stuart Wolf, Oliver Sartor, Eric Klein, Carol Hahn, Jeff Michalski, Mack Roach, Martha M. Faraday

Research output: Contribution to journalArticle

123 Scopus citations

Abstract

Purpose The purpose of this guideline was to provide a clinical framework for the use of radiation therapy after radical prostatectomy as adjuvant or salvage therapy. Methods and Materials A systematic literature review using PubMed, Embase, and Cochrane database was conducted to identify peer-reviewed publications relevant to the use of radiation therapy after prostatectomy. The review yielded 294 articles; these publications were used to create the evidence-based guideline statements. Additional guidance is provided as Clinical Principles when insufficient evidence existed. Results Guideline statements are provided for patient counseling, use of radiation therapy in the adjuvant and salvage contexts, defining biochemical recurrence, and conducting a restaging evaluation. Conclusions Physicians should offer adjuvant radiation therapy to patients with adverse pathologic findings at prostatectomy (ie, seminal vesicle invastion, positive surgical margins, extraprostatic extension) and salvage radiation therapy to patients with prostate-specific antigen (PSA) or local recurrence after prostatectomy in whom there is no evidence of distant metastatic disease. The offer of radiation therapy should be made in the context of a thoughtful discussion of possible short- and long-term side effects of radiation therapy as well as the potential benefits of preventing recurrence. The decision to administer radiation therapy should be made by the patient and the multidisciplinary treatment team with full consideration of the patient's history, values, preferences, quality of life, and functional status. The American Society for Radiation Oncology and American Urological Association websites show this guideline in its entirety, including the full literature review.

Original languageEnglish (US)
Pages (from-to)822-828
Number of pages7
JournalInternational Journal of Radiation Oncology Biology Physics
Volume86
Issue number5
DOIs
StatePublished - Aug 1 2013

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research

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    Valicenti, R. K., Thompson, I., Albertsen, P., Davis, B. J., Goldenberg, S. L., Wolf, J. S., Sartor, O., Klein, E., Hahn, C., Michalski, J., Roach, M., & Faraday, M. M. (2013). Adjuvant and salvage radiation therapy after prostatectomy: American society for radiation oncology/american urological association guidelines. International Journal of Radiation Oncology Biology Physics, 86(5), 822-828. https://doi.org/10.1016/j.ijrobp.2013.05.029