Adiposity and reporting of vasomotor symptoms among midlife women

Rebecca C. Thurston, MaryFran R. Sowers, Yuefang Chang, Barbara Sternfeld, Ellen B Gold, Janet M. Johnston, Karen A. Matthews

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

It has long been hypothesized that increased adiposity would be associated with decreased vasomotor symptoms during menopause because of conversion of androgens to estrogens in body fat. However, recent thermoregulatory models have postulated that increased adipose tissue would be associated with a greater likelihood of vasomotor symptoms. The authors evaluated these hypotheses in the Study of Women's Health Across the Nation, a multiethnic, community-based observational study of US women transitioning through menopause. The sample included 1,776 women aged 47-59 years with an intact uterus and at least one ovary who completed bioelectrical impedance analysis for assessment of body composition at the sixth annual study visit (2002-2004). Assessments also included reported vasomotor symptoms (hot flashes, night sweats) and serum levels of follicle-stimulating hormone, estradiol, and sex hormone-binding globulin-adjusted estradiol (free estradiol index). Results indicated that a higher percentage of body fat was associated with increased odds of reporting vasomotor symptoms (per standard deviation increase in percent body fat, odds ratio = 1.27, 95% confidence interval: 1.14, 1.42) in age- and site-adjusted models. Associations persisted in fully adjusted models and were not reduced when models included reproductive hormones. These findings support a thermoregulatory model of vasomotor symptoms.

Original languageEnglish (US)
Pages (from-to)78-85
Number of pages8
JournalAmerican Journal of Epidemiology
Volume167
Issue number1
DOIs
StatePublished - Jan 2008

Fingerprint

Adiposity
Adipose Tissue
Estradiol
Menopause
Hot Flashes
Sex Hormone-Binding Globulin
Sweat
Follicle Stimulating Hormone
Women's Health
Body Composition
Electric Impedance
Androgens
Uterus
Observational Studies
Ovary
Estrogens
Odds Ratio
Hormones
Confidence Intervals
Serum

Keywords

  • Adipose tissue
  • Adiposity
  • Body composition
  • Body fat distribution
  • Climacteric
  • Hot flashes
  • Menopause

ASJC Scopus subject areas

  • Epidemiology

Cite this

Thurston, R. C., Sowers, M. R., Chang, Y., Sternfeld, B., Gold, E. B., Johnston, J. M., & Matthews, K. A. (2008). Adiposity and reporting of vasomotor symptoms among midlife women. American Journal of Epidemiology, 167(1), 78-85. https://doi.org/10.1093/aje/kwm244

Adiposity and reporting of vasomotor symptoms among midlife women. / Thurston, Rebecca C.; Sowers, MaryFran R.; Chang, Yuefang; Sternfeld, Barbara; Gold, Ellen B; Johnston, Janet M.; Matthews, Karen A.

In: American Journal of Epidemiology, Vol. 167, No. 1, 01.2008, p. 78-85.

Research output: Contribution to journalArticle

Thurston, RC, Sowers, MR, Chang, Y, Sternfeld, B, Gold, EB, Johnston, JM & Matthews, KA 2008, 'Adiposity and reporting of vasomotor symptoms among midlife women', American Journal of Epidemiology, vol. 167, no. 1, pp. 78-85. https://doi.org/10.1093/aje/kwm244
Thurston, Rebecca C. ; Sowers, MaryFran R. ; Chang, Yuefang ; Sternfeld, Barbara ; Gold, Ellen B ; Johnston, Janet M. ; Matthews, Karen A. / Adiposity and reporting of vasomotor symptoms among midlife women. In: American Journal of Epidemiology. 2008 ; Vol. 167, No. 1. pp. 78-85.
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