Adipose tissue hyperplasia and hyperinsulinemia in Zucker obese female rats: A developmental study

P. R. Johnson, J. S. Stern, M. R C Greenwood, Jules Hirsch

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Obese female Zucker rats show persistent increases in fat cell number compared to lean female Zucker rats from 5 to 52 wk of age. The hyperplastic obesity of the Zucker rat is also accompanied by fat cell hypertrophy and elevated plasma immunoreactive insulin (IRI). Average adipocyte size reaches a peak value at 14 wk of age in the subcutaneous, retroperitoneal and parametrial depots of the female obese rat. Plasma IRI also shows a peak at 14 wk of age. In addition, at this age thymidine kinase activity, a measure of proliferative capacity in tissue, is elevated in obese compared to lean rats, and at 15 1 2 wk of age a bimodal distribution of adipocytes is present in obese rat adipose tissue. The data suggest that attainment of a critical adipocyte size accompanied by maximum levels of plasma IRI may act in concert to potentiate fat cell hyperplasia in Zucker obese rats.

Original languageEnglish (US)
Pages (from-to)1941-1954
Number of pages14
JournalMetabolism
Volume27
Issue number12 SUPPL. 2
StatePublished - Dec 1978
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Johnson, P. R., Stern, J. S., Greenwood, M. R. C., & Hirsch, J. (1978). Adipose tissue hyperplasia and hyperinsulinemia in Zucker obese female rats: A developmental study. Metabolism, 27(12 SUPPL. 2), 1941-1954.