Adipose tissue dysfunction in nascent metabolic syndrome

Andrew A. Bremer, Ishwarlal Jialal

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

The metabolic syndrome (MetS) confers an increased risk for both type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Moreover, studies on adipose tissue biology in nascent MetS uncomplicated by T2DM and/or CVD are scanty. Recently, we demonstrated that adipose tissue dysregulation and aberrant adipokine secretion contribute towards the syndrome's low-grade chronic proinflammatory state and insulin resistance. Specifically, we have made the novel observation that subcutaneous adipose tissue (SAT) in subjects with nascent MetS has increased macrophage recruitment with cardinal crown-like structures. We have also shown that subjects with nascent MetS have increased the levels of SAT-secreted adipokines (IL-1, IL-6, IL-8, leptin, RBP-4, CRP, SAA, PAI-1, MCP-1, and chemerin) and plasma adipokines (IL-1, IL-6, leptin, RBP-4, CRP, SAA, and chemerin), as well as decreased levels of plasma adiponectin and both plasma and SAT omentin-1. The majority of these abnormalities persisted following correction for increased adiposity. Our data, as well as data from other investigators, thus, highlight the importance of subcutaneous adipose tissue dysfunction in subjects with MetS and its contribution to the proinflammatory state and insulin resistance. This adipokine profile may contribute to increased insulin resistance and low-grade inflammation, promoting the increased risk of T2DM and CVD.

Original languageEnglish (US)
Article number393192
JournalJournal of Obesity
Volume2013
DOIs
StatePublished - 2013

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Adipose Tissue
Adipokines
Subcutaneous Fat
Type 2 Diabetes Mellitus
Insulin Resistance
Cardiovascular Diseases
Leptin
Interleukin-1
Interleukin-6
Adiponectin
Plasminogen Activator Inhibitor 1
Adiposity
Crowns
Interleukin-8
Macrophages
Research Personnel
Observation
Inflammation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Adipose tissue dysfunction in nascent metabolic syndrome. / Bremer, Andrew A.; Jialal, Ishwarlal.

In: Journal of Obesity, Vol. 2013, 393192, 2013.

Research output: Contribution to journalArticle

Bremer, Andrew A. ; Jialal, Ishwarlal. / Adipose tissue dysfunction in nascent metabolic syndrome. In: Journal of Obesity. 2013 ; Vol. 2013.
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