Adipose tissue-derived stem cells ameliorate diabetic bladder dysfunction in a type II diabetic rat model

Haiyang Zhang, Xuefeng Qiu, Alan W Shindel, Hongxiu Ning, Ludovic Ferretti, Xunbo Jin, Guiting Lin, Ching Shwun Lin, Tom F. Lue

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Diabetes mellitus is associated with a broad constellation of voiding complaints that are often multifactorial and resistant to currently available therapies. The leading causes of diabetic bladder dysfunction (DBD) include alterations in the bladder smooth muscle, neuronal degeneration, and urothelial dysfunction. Adipose tissue-derived stem cells (ADSCs), a type of mesenchymal stromal cells, have shown promise as a novel tissue regenerative technique that may have utility in DBD. The aim of this study is to determine the efficacy and mechanism by which ADSCs may ameliorate DBD in rats fed a high-fat diet and treated with low-dose streptozotocin to induce type II diabetes. Improved voiding function was noted in ADSCs-treated rats as compared with phosphate-buffered saline-treated rats. Though some ADSCs differentiated into smooth muscle cells, paracrine pathway seems to play a main role in this process, thus resulting in reduction of apoptosis and preservation of "suburothelial capillaries network".

Original languageEnglish (US)
Pages (from-to)1391-1400
Number of pages10
JournalStem Cells and Development
Volume21
Issue number9
DOIs
StatePublished - Jun 10 2012

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Hematology

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