Adipose lipoprotein lipase in insulin-treated diabetic lean and obese Zucker rats.

C. P. Chan, J. S. Stern

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Obese and lean alloxan-diabetic rats were given daily injections of insulin for 9 days. Plasma glucose and insulin concentrations were not different between the two genotypes given comparable amounts of insulin. Carcass fat and epididymal and retroperitoneal fat pad weights increased as the dose of insulin was increased. At each of four doses, fatties had larger fat cells, bigger pads, and more body fat than lean rats. Adipose lipoprotein lipase (LPL) activity per pad or per fat cell was increased by insulin. Except for the lowest dose of insulin, LPL activity was higher in obese rats than in lean rats. LPL activity per cell and cell size were highly correlated. However, when differences in cell size were corrected for, no significant effect of genotype existed. Cardiac LPL activities were different between the two genotypes only in nondiabetic rats. These results suggested that both insulin and some other genetic factors were important in elevating adipose LPL activities and thus fat deposition in obese Zucker rats.

Original languageEnglish (US)
JournalThe American journal of physiology
Volume242
Issue number6
StatePublished - Jun 1982

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Zucker Rats
Lipoprotein Lipase
Insulin
Genotype
Cell Size
Adipocytes
Adipose Tissue
Fats
Alloxan
Intra-Abdominal Fat
Weights and Measures
Glucose
Injections

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Adipose lipoprotein lipase in insulin-treated diabetic lean and obese Zucker rats. / Chan, C. P.; Stern, J. S.

In: The American journal of physiology, Vol. 242, No. 6, 06.1982.

Research output: Contribution to journalArticle

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