Abstract
The relationship between adipose-cell size and plasma levels of immunoreactive insulin (I.R.I.) was studied in 73 normal and obese individuals and in 12 obese patients before and after weight reduction. A strong positive correlation was found between adipose-cell size and fasting I.R.I. in both groups. This relation exists despite the widely differing degrees of obesity (and, therefore, their probable different total carbohydrate intakes). It is suggested that the increased adipose-cell size seen in obesity could sensitise the pancreas to produce more insulin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 948-951 |
| Number of pages | 4 |
| Journal | The Lancet |
| Volume | 300 |
| Issue number | 7784 |
| DOIs | |
| State | Published - Nov 4 1972 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
ADIPOSE-CELL SIZE AND IMMUNOREACTIVE INSULIN LEVELS IN OBESE AND NORMAL-WEIGHT ADULTS. / Stern, JudithS; Hollander, Nina; Batchelor, BruceR; Cohn, CalK; Hirsch, Jules.
In: The Lancet, Vol. 300, No. 7784, 04.11.1972, p. 948-951.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - ADIPOSE-CELL SIZE AND IMMUNOREACTIVE INSULIN LEVELS IN OBESE AND NORMAL-WEIGHT ADULTS
AU - Stern, JudithS
AU - Hollander, Nina
AU - Batchelor, BruceR
AU - Cohn, CalK
AU - Hirsch, Jules
PY - 1972/11/4
Y1 - 1972/11/4
N2 - The relationship between adipose-cell size and plasma levels of immunoreactive insulin (I.R.I.) was studied in 73 normal and obese individuals and in 12 obese patients before and after weight reduction. A strong positive correlation was found between adipose-cell size and fasting I.R.I. in both groups. This relation exists despite the widely differing degrees of obesity (and, therefore, their probable different total carbohydrate intakes). It is suggested that the increased adipose-cell size seen in obesity could sensitise the pancreas to produce more insulin.
AB - The relationship between adipose-cell size and plasma levels of immunoreactive insulin (I.R.I.) was studied in 73 normal and obese individuals and in 12 obese patients before and after weight reduction. A strong positive correlation was found between adipose-cell size and fasting I.R.I. in both groups. This relation exists despite the widely differing degrees of obesity (and, therefore, their probable different total carbohydrate intakes). It is suggested that the increased adipose-cell size seen in obesity could sensitise the pancreas to produce more insulin.
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UR - http://www.scopus.com/inward/citedby.url?scp=0015494227&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(72)92474-9
DO - 10.1016/S0140-6736(72)92474-9
M3 - Article
C2 - 4116826
AN - SCOPUS:0015494227
VL - 300
SP - 948
EP - 951
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 7784
ER -