ADIPOSE-CELL SIZE AND IMMUNOREACTIVE INSULIN LEVELS IN OBESE AND NORMAL-WEIGHT ADULTS

JudithS Stern; Nina Hollander; BruceR Batchelor; CalK Cohn; Jules Hirsch

doi:10.1016/S0140-6736(72)92474-9

ADIPOSE-CELL SIZE AND IMMUNOREACTIVE INSULIN LEVELS IN OBESE AND NORMAL-WEIGHT ADULTS

JudithS Stern, Nina Hollander, BruceR Batchelor, CalK Cohn, Jules Hirsch

Research output: Contribution to journal › Article › peer-review

94 Scopus citations

Abstract

The relationship between adipose-cell size and plasma levels of immunoreactive insulin (I.R.I.) was studied in 73 normal and obese individuals and in 12 obese patients before and after weight reduction. A strong positive correlation was found between adipose-cell size and fasting I._R._I. in both groups. This relation exists despite the widely differing degrees of obesity (and, therefore, their probable different total carbohydrate intakes). It is suggested that the increased adipose-cell size seen in obesity could sensitise the pancreas to produce more insulin.

Original language	English (US)
Pages (from-to)	948-951
Number of pages	4
Journal	The Lancet
Volume	300
Issue number	7784
DOIs	https://doi.org/10.1016/S0140-6736(72)92474-9
State	Published - Nov 4 1972
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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abstract = "The relationship between adipose-cell size and plasma levels of immunoreactive insulin (I.R.I.) was studied in 73 normal and obese individuals and in 12 obese patients before and after weight reduction. A strong positive correlation was found between adipose-cell size and fasting I.R.I. in both groups. This relation exists despite the widely differing degrees of obesity (and, therefore, their probable different total carbohydrate intakes). It is suggested that the increased adipose-cell size seen in obesity could sensitise the pancreas to produce more insulin.",

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AU - Cohn, CalK

AU - Hirsch, Jules

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AB - The relationship between adipose-cell size and plasma levels of immunoreactive insulin (I.R.I.) was studied in 73 normal and obese individuals and in 12 obese patients before and after weight reduction. A strong positive correlation was found between adipose-cell size and fasting I.R.I. in both groups. This relation exists despite the widely differing degrees of obesity (and, therefore, their probable different total carbohydrate intakes). It is suggested that the increased adipose-cell size seen in obesity could sensitise the pancreas to produce more insulin.

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ER -

ADIPOSE-CELL SIZE AND IMMUNOREACTIVE INSULIN LEVELS IN OBESE AND NORMAL-WEIGHT ADULTS

Abstract

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