ADIPOSE-CELL SIZE AND IMMUNOREACTIVE INSULIN LEVELS IN OBESE AND NORMAL-WEIGHT ADULTS

JudithS Stern, Nina Hollander, BruceR Batchelor, CalK Cohn, Jules Hirsch

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

The relationship between adipose-cell size and plasma levels of immunoreactive insulin (I.R.I.) was studied in 73 normal and obese individuals and in 12 obese patients before and after weight reduction. A strong positive correlation was found between adipose-cell size and fasting I.R.I. in both groups. This relation exists despite the widely differing degrees of obesity (and, therefore, their probable different total carbohydrate intakes). It is suggested that the increased adipose-cell size seen in obesity could sensitise the pancreas to produce more insulin.

Original languageEnglish (US)
Pages (from-to)948-951
Number of pages4
JournalThe Lancet
Volume300
Issue number7784
DOIs
StatePublished - Nov 4 1972
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Stern, J., Hollander, N., Batchelor, B., Cohn, C., & Hirsch, J. (1972). ADIPOSE-CELL SIZE AND IMMUNOREACTIVE INSULIN LEVELS IN OBESE AND NORMAL-WEIGHT ADULTS. The Lancet, 300(7784), 948-951. https://doi.org/10.1016/S0140-6736(72)92474-9