ADIPOSE-CELL SIZE AND IMMUNOREACTIVE INSULIN LEVELS IN OBESE AND NORMAL-WEIGHT ADULTS

JudithS Stern; Nina Hollander; BruceR Batchelor; CalK Cohn; Jules Hirsch

doi:10.1016/S0140-6736(72)92474-9

ADIPOSE-CELL SIZE AND IMMUNOREACTIVE INSULIN LEVELS IN OBESE AND NORMAL-WEIGHT ADULTS

JudithS Stern, Nina Hollander, BruceR Batchelor, CalK Cohn, Jules Hirsch

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

The relationship between adipose-cell size and plasma levels of immunoreactive insulin (I.R.I.) was studied in 73 normal and obese individuals and in 12 obese patients before and after weight reduction. A strong positive correlation was found between adipose-cell size and fasting I._R._I. in both groups. This relation exists despite the widely differing degrees of obesity (and, therefore, their probable different total carbohydrate intakes). It is suggested that the increased adipose-cell size seen in obesity could sensitise the pancreas to produce more insulin.

Original language	English (US)
Pages (from-to)	948-951
Number of pages	4
Journal	The Lancet
Volume	300
Issue number	7784
DOIs	https://doi.org/10.1016/S0140-6736(72)92474-9
State	Published - Nov 4 1972
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1016/S0140-6736(72)92474-9

Cite this

@article{03fcd98334b04640a21562081409ad82,

title = "ADIPOSE-CELL SIZE AND IMMUNOREACTIVE INSULIN LEVELS IN OBESE AND NORMAL-WEIGHT ADULTS",

abstract = "The relationship between adipose-cell size and plasma levels of immunoreactive insulin (I.R.I.) was studied in 73 normal and obese individuals and in 12 obese patients before and after weight reduction. A strong positive correlation was found between adipose-cell size and fasting I.R.I. in both groups. This relation exists despite the widely differing degrees of obesity (and, therefore, their probable different total carbohydrate intakes). It is suggested that the increased adipose-cell size seen in obesity could sensitise the pancreas to produce more insulin.",

author = "JudithS Stern and Nina Hollander and BruceR Batchelor and CalK Cohn and Jules Hirsch",

year = "1972",

month = nov,

day = "4",

doi = "10.1016/S0140-6736(72)92474-9",

language = "English (US)",

volume = "300",

pages = "948--951",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier Limited",

number = "7784",

}

TY - JOUR

T1 - ADIPOSE-CELL SIZE AND IMMUNOREACTIVE INSULIN LEVELS IN OBESE AND NORMAL-WEIGHT ADULTS

AU - Stern, JudithS

AU - Hollander, Nina

AU - Batchelor, BruceR

AU - Cohn, CalK

AU - Hirsch, Jules

PY - 1972/11/4

Y1 - 1972/11/4

N2 - The relationship between adipose-cell size and plasma levels of immunoreactive insulin (I.R.I.) was studied in 73 normal and obese individuals and in 12 obese patients before and after weight reduction. A strong positive correlation was found between adipose-cell size and fasting I.R.I. in both groups. This relation exists despite the widely differing degrees of obesity (and, therefore, their probable different total carbohydrate intakes). It is suggested that the increased adipose-cell size seen in obesity could sensitise the pancreas to produce more insulin.

AB - The relationship between adipose-cell size and plasma levels of immunoreactive insulin (I.R.I.) was studied in 73 normal and obese individuals and in 12 obese patients before and after weight reduction. A strong positive correlation was found between adipose-cell size and fasting I.R.I. in both groups. This relation exists despite the widely differing degrees of obesity (and, therefore, their probable different total carbohydrate intakes). It is suggested that the increased adipose-cell size seen in obesity could sensitise the pancreas to produce more insulin.

UR - http://www.scopus.com/inward/record.url?scp=0015494227&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015494227&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(72)92474-9

DO - 10.1016/S0140-6736(72)92474-9

M3 - Article

C2 - 4116826

AN - SCOPUS:0015494227

VL - 300

SP - 948

EP - 951

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 7784

ER -

ADIPOSE-CELL SIZE AND IMMUNOREACTIVE INSULIN LEVELS IN OBESE AND NORMAL-WEIGHT ADULTS

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this