Adiponectin and the development of type 2 diabetes

The atherosclerosis risk in communities study

Bruce B. Duncan, Maria Inês Schmidt, James S. Pankow, Heejung Bang, David Couper, Christie M. Ballantyne, Ron C. Hoogeveen, Gerardo Heiss

Research output: Contribution to journalArticle

265 Citations (Scopus)

Abstract

Adipocyte-derived secretory proteins have been increasingly linked to diabetes. To investigate whether adiponectin, a major adipocyte secretory protein, predicts diabetes, we conducted a case-cohort study representing the ∼9-year experience of the 10,275 middle-aged, U.S. African-American and white participants of the Atherosclerosis Risk in Communities (ARIC) study. Adiponectin was measured on stored plasma of 581 incident diabetes case subjects and 572 noncase subjects. Overall hazard ratios (95% CIs) for developing diabetes, for those in the second, third, and fourth (versus the first) quartile of adiponectin were 0.57 (0.41-0.78), 0.39 (0.27-0.56), and 0.18 (0.11-0.27), respectively, after adjustment for age, sex, ethnicity, study center, parental history of diabetes, and hypertension and 0.72 (0.48-1.09), 0.67 (0.43-1.04), and 0.58 (0.34-0.99), respectively, after additional adjustment for BMI, waist-to-hip ratio, fasting glucose, insulin, and a score composed of six inflammation markers. The association was of similar magnitude in men and women and in whites and African Americans, but was absent in smokers and in those with a greater inflammation score (interaction P < 0.01 for each). In conclusion, in this community-based sample of U.S. adults, higher adiponectin levels were associated with a lower incidence of diabetes.

Original languageEnglish (US)
Pages (from-to)2473-2478
Number of pages6
JournalDiabetes
Volume53
Issue number9
DOIs
StatePublished - Sep 2004
Externally publishedYes

Fingerprint

Adiponectin
Type 2 Diabetes Mellitus
Atherosclerosis
Adipocytes
African Americans
Inflammation
Waist-Hip Ratio
Fasting
Proteins
Cohort Studies
Insulin
Hypertension
Glucose
Incidence

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Duncan, B. B., Schmidt, M. I., Pankow, J. S., Bang, H., Couper, D., Ballantyne, C. M., ... Heiss, G. (2004). Adiponectin and the development of type 2 diabetes: The atherosclerosis risk in communities study. Diabetes, 53(9), 2473-2478. https://doi.org/10.2337/diabetes.53.9.2473

Adiponectin and the development of type 2 diabetes : The atherosclerosis risk in communities study. / Duncan, Bruce B.; Schmidt, Maria Inês; Pankow, James S.; Bang, Heejung; Couper, David; Ballantyne, Christie M.; Hoogeveen, Ron C.; Heiss, Gerardo.

In: Diabetes, Vol. 53, No. 9, 09.2004, p. 2473-2478.

Research output: Contribution to journalArticle

Duncan, BB, Schmidt, MI, Pankow, JS, Bang, H, Couper, D, Ballantyne, CM, Hoogeveen, RC & Heiss, G 2004, 'Adiponectin and the development of type 2 diabetes: The atherosclerosis risk in communities study', Diabetes, vol. 53, no. 9, pp. 2473-2478. https://doi.org/10.2337/diabetes.53.9.2473
Duncan, Bruce B. ; Schmidt, Maria Inês ; Pankow, James S. ; Bang, Heejung ; Couper, David ; Ballantyne, Christie M. ; Hoogeveen, Ron C. ; Heiss, Gerardo. / Adiponectin and the development of type 2 diabetes : The atherosclerosis risk in communities study. In: Diabetes. 2004 ; Vol. 53, No. 9. pp. 2473-2478.
@article{a0851ade9ded487b92586cf1630eb0ce,
title = "Adiponectin and the development of type 2 diabetes: The atherosclerosis risk in communities study",
abstract = "Adipocyte-derived secretory proteins have been increasingly linked to diabetes. To investigate whether adiponectin, a major adipocyte secretory protein, predicts diabetes, we conducted a case-cohort study representing the ∼9-year experience of the 10,275 middle-aged, U.S. African-American and white participants of the Atherosclerosis Risk in Communities (ARIC) study. Adiponectin was measured on stored plasma of 581 incident diabetes case subjects and 572 noncase subjects. Overall hazard ratios (95{\%} CIs) for developing diabetes, for those in the second, third, and fourth (versus the first) quartile of adiponectin were 0.57 (0.41-0.78), 0.39 (0.27-0.56), and 0.18 (0.11-0.27), respectively, after adjustment for age, sex, ethnicity, study center, parental history of diabetes, and hypertension and 0.72 (0.48-1.09), 0.67 (0.43-1.04), and 0.58 (0.34-0.99), respectively, after additional adjustment for BMI, waist-to-hip ratio, fasting glucose, insulin, and a score composed of six inflammation markers. The association was of similar magnitude in men and women and in whites and African Americans, but was absent in smokers and in those with a greater inflammation score (interaction P < 0.01 for each). In conclusion, in this community-based sample of U.S. adults, higher adiponectin levels were associated with a lower incidence of diabetes.",
author = "Duncan, {Bruce B.} and Schmidt, {Maria In{\^e}s} and Pankow, {James S.} and Heejung Bang and David Couper and Ballantyne, {Christie M.} and Hoogeveen, {Ron C.} and Gerardo Heiss",
year = "2004",
month = "9",
doi = "10.2337/diabetes.53.9.2473",
language = "English (US)",
volume = "53",
pages = "2473--2478",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association Inc.",
number = "9",

}

TY - JOUR

T1 - Adiponectin and the development of type 2 diabetes

T2 - The atherosclerosis risk in communities study

AU - Duncan, Bruce B.

AU - Schmidt, Maria Inês

AU - Pankow, James S.

AU - Bang, Heejung

AU - Couper, David

AU - Ballantyne, Christie M.

AU - Hoogeveen, Ron C.

AU - Heiss, Gerardo

PY - 2004/9

Y1 - 2004/9

N2 - Adipocyte-derived secretory proteins have been increasingly linked to diabetes. To investigate whether adiponectin, a major adipocyte secretory protein, predicts diabetes, we conducted a case-cohort study representing the ∼9-year experience of the 10,275 middle-aged, U.S. African-American and white participants of the Atherosclerosis Risk in Communities (ARIC) study. Adiponectin was measured on stored plasma of 581 incident diabetes case subjects and 572 noncase subjects. Overall hazard ratios (95% CIs) for developing diabetes, for those in the second, third, and fourth (versus the first) quartile of adiponectin were 0.57 (0.41-0.78), 0.39 (0.27-0.56), and 0.18 (0.11-0.27), respectively, after adjustment for age, sex, ethnicity, study center, parental history of diabetes, and hypertension and 0.72 (0.48-1.09), 0.67 (0.43-1.04), and 0.58 (0.34-0.99), respectively, after additional adjustment for BMI, waist-to-hip ratio, fasting glucose, insulin, and a score composed of six inflammation markers. The association was of similar magnitude in men and women and in whites and African Americans, but was absent in smokers and in those with a greater inflammation score (interaction P < 0.01 for each). In conclusion, in this community-based sample of U.S. adults, higher adiponectin levels were associated with a lower incidence of diabetes.

AB - Adipocyte-derived secretory proteins have been increasingly linked to diabetes. To investigate whether adiponectin, a major adipocyte secretory protein, predicts diabetes, we conducted a case-cohort study representing the ∼9-year experience of the 10,275 middle-aged, U.S. African-American and white participants of the Atherosclerosis Risk in Communities (ARIC) study. Adiponectin was measured on stored plasma of 581 incident diabetes case subjects and 572 noncase subjects. Overall hazard ratios (95% CIs) for developing diabetes, for those in the second, third, and fourth (versus the first) quartile of adiponectin were 0.57 (0.41-0.78), 0.39 (0.27-0.56), and 0.18 (0.11-0.27), respectively, after adjustment for age, sex, ethnicity, study center, parental history of diabetes, and hypertension and 0.72 (0.48-1.09), 0.67 (0.43-1.04), and 0.58 (0.34-0.99), respectively, after additional adjustment for BMI, waist-to-hip ratio, fasting glucose, insulin, and a score composed of six inflammation markers. The association was of similar magnitude in men and women and in whites and African Americans, but was absent in smokers and in those with a greater inflammation score (interaction P < 0.01 for each). In conclusion, in this community-based sample of U.S. adults, higher adiponectin levels were associated with a lower incidence of diabetes.

UR - http://www.scopus.com/inward/record.url?scp=4344665855&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4344665855&partnerID=8YFLogxK

U2 - 10.2337/diabetes.53.9.2473

DO - 10.2337/diabetes.53.9.2473

M3 - Article

VL - 53

SP - 2473

EP - 2478

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 9

ER -