Adhesion molecules associated with female genital tract infection

Jamal Qualai, Jon Cantero, Lin Xi Li, José Manuel Carrascosa, Eduard Cabré, Olga Dern, Lauro Sumoy, Gerard Requena, Stephen J Mcsorley, Meritxell Genescà

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Efforts to develop vaccines that can elicit mucosal immune responses in the female genital tract against sexually transmitted infections have been hampered by an inability to measure immune responses in these tissues. The differential expression of adhesion molecules is known to confer site-dependent homing of circulating effector T cells to mucosal tissues. Specific homing molecules have been defined that can be measured in blood as surrogate markers of local immunity (e.g. α4β7 for gut). Here we analyzed the expression pattern of adhesion molecules by circulating effector T cells following mucosal infection of the female genital tract in mice and during a symptomatic episode of vaginosis in women. While CCR2, CCR5, CXCR6 and CD11c were preferentially expressed in a mouse model of Chlamydia infection, only CCR5 and CD11c were clearly expressed by effector T cells during bacterial vaginosis in women. Other homing molecules previously suggested as required for homing to the genital mucosa such as α4β1 and α4β7 were also differentially expressed in these patients. However, CD11c expression, an integrin chain rarely analyzed in the context of T cell immunity, was the most consistently elevated in all activated effector CD8+ T cell subsets analyzed. This molecule was also induced after systemic infection in mice, suggesting that CD11c is not exclusive of genital tract infection. Still, its increase in response to genital tract disorders may represent a novel surrogate marker of mucosal immunity in women, and warrants further exploration for diagnostic and therapeutic purposes.

Original languageEnglish (US)
Article numbere0156605
JournalPLoS One
Volume11
Issue number6
DOIs
StatePublished - Jun 1 2016

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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    Qualai, J., Cantero, J., Li, L. X., Carrascosa, J. M., Cabré, E., Dern, O., Sumoy, L., Requena, G., Mcsorley, S. J., & Genescà, M. (2016). Adhesion molecules associated with female genital tract infection. PLoS One, 11(6), [e0156605]. https://doi.org/10.1371/journal.pone.0156605