Adequacy of Early Empiric Antibiotic Treatment and Survival in Severe Sepsis: Experience from the MONARCS Trial

Rodger D. MacArthur, Mark Miller, Timothy E Albertson, Edward A Panacek, David Johnson, Leah Teoh, William Barchuk

Research output: Contribution to journalArticle

191 Scopus citations


As part of the Monoclonal Anti-TNF: A Randomized Controlled Sepsis (MONARCS) trial, which enrolled patients with suspected sepsis, we sought to determine whether adequate antibiotic therapy was associated with a decreased mortality rate. The study enrolled 2634 patients, 91% of whom received adequate antibiotic therapy. The mortality rate among patients given adequate antibiotic treatment was 33%, versus 43% among patients given inadequate treatment (P < .001). We conclude that adequate antibiotic therapy results in a significant decrease in the crude mortality rate among patients suspected of sepsis.

Original languageEnglish (US)
Pages (from-to)284-288
Number of pages5
JournalClinical Infectious Diseases
Issue number2
StatePublished - Jan 15 2004


ASJC Scopus subject areas

  • Immunology

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