Adenosinergic modulation of the EEG and locomotor effects of the A2 agonist, CGS 21680

Cynthia A. Janusz; Robert F Berman

doi:10.1016/0091-3057(93)90139-K

Adenosinergic modulation of the EEG and locomotor effects of the A₂ agonist, CGS 21680

Cynthia A. Janusz, Robert F Berman

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The present study in rats was designed to identify the respective roles of A₁ and A₂ adenosine receptor activation in the anticonvulsant and behavioral actions of adenosine. Intracaudate injections of the highly selective A₂ agonist, CGS 21680, did not affect caudate seizures. However, seizure threshold was increased in the presence of CGS 21680 after blockade of the A₁ receptor with CPX, or following activation of the A₁ receptor with R-PIA or NECA. Additionally, CGS 21680 led to a dose-related inhibition of locomotor activity when injected into the caudate. These results implicate the involvement of the A₂ adenosine receptor in the locomotor depressant actions of adenosine and also suggest possible A₂ anticonvulsant effects may depend upon the activation of the A₁ receptor.

Original language	English (US)
Pages (from-to)	913-919
Number of pages	7
Journal	Pharmacology, Biochemistry and Behavior
Volume	45
Issue number	4
DOIs	https://doi.org/10.1016/0091-3057(93)90139-K
State	Published - 1993
Externally published	Yes

Keywords

Adenosine
Alkylxanthine
Anticonvulsant
Caudate nucleus
Locomotor activity

ASJC Scopus subject areas

Biochemistry
Behavioral Neuroscience
Pharmacology

Access to Document

10.1016/0091-3057(93)90139-K

Cite this

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title = "Adenosinergic modulation of the EEG and locomotor effects of the A2 agonist, CGS 21680",

abstract = "The present study in rats was designed to identify the respective roles of A1 and A2 adenosine receptor activation in the anticonvulsant and behavioral actions of adenosine. Intracaudate injections of the highly selective A2 agonist, CGS 21680, did not affect caudate seizures. However, seizure threshold was increased in the presence of CGS 21680 after blockade of the A1 receptor with CPX, or following activation of the A1 receptor with R-PIA or NECA. Additionally, CGS 21680 led to a dose-related inhibition of locomotor activity when injected into the caudate. These results implicate the involvement of the A2 adenosine receptor in the locomotor depressant actions of adenosine and also suggest possible A2 anticonvulsant effects may depend upon the activation of the A1 receptor.",

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AU - Janusz, Cynthia A.

AU - Berman, Robert F

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AB - The present study in rats was designed to identify the respective roles of A1 and A2 adenosine receptor activation in the anticonvulsant and behavioral actions of adenosine. Intracaudate injections of the highly selective A2 agonist, CGS 21680, did not affect caudate seizures. However, seizure threshold was increased in the presence of CGS 21680 after blockade of the A1 receptor with CPX, or following activation of the A1 receptor with R-PIA or NECA. Additionally, CGS 21680 led to a dose-related inhibition of locomotor activity when injected into the caudate. These results implicate the involvement of the A2 adenosine receptor in the locomotor depressant actions of adenosine and also suggest possible A2 anticonvulsant effects may depend upon the activation of the A1 receptor.

KW - Adenosine

KW - Alkylxanthine

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KW - Caudate nucleus

KW - Locomotor activity

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