Abstract
The present study in rats was designed to identify the respective roles of A1 and A2 adenosine receptor activation in the anticonvulsant and behavioral actions of adenosine. Intracaudate injections of the highly selective A2 agonist, CGS 21680, did not affect caudate seizures. However, seizure threshold was increased in the presence of CGS 21680 after blockade of the A1 receptor with CPX, or following activation of the A1 receptor with R-PIA or NECA. Additionally, CGS 21680 led to a dose-related inhibition of locomotor activity when injected into the caudate. These results implicate the involvement of the A2 adenosine receptor in the locomotor depressant actions of adenosine and also suggest possible A2 anticonvulsant effects may depend upon the activation of the A1 receptor.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 913-919 |
| Number of pages | 7 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 45 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1993 |
| Externally published | Yes |
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Keywords
- Adenosine
- Alkylxanthine
- Anticonvulsant
- Caudate nucleus
- Locomotor activity
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology
Cite this
Adenosinergic modulation of the EEG and locomotor effects of the A2 agonist, CGS 21680. / Janusz, Cynthia A.; Berman, Robert F.
In: Pharmacology, Biochemistry and Behavior, Vol. 45, No. 4, 1993, p. 913-919.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adenosinergic modulation of the EEG and locomotor effects of the A2 agonist, CGS 21680
AU - Janusz, Cynthia A.
AU - Berman, Robert F
PY - 1993
Y1 - 1993
N2 - The present study in rats was designed to identify the respective roles of A1 and A2 adenosine receptor activation in the anticonvulsant and behavioral actions of adenosine. Intracaudate injections of the highly selective A2 agonist, CGS 21680, did not affect caudate seizures. However, seizure threshold was increased in the presence of CGS 21680 after blockade of the A1 receptor with CPX, or following activation of the A1 receptor with R-PIA or NECA. Additionally, CGS 21680 led to a dose-related inhibition of locomotor activity when injected into the caudate. These results implicate the involvement of the A2 adenosine receptor in the locomotor depressant actions of adenosine and also suggest possible A2 anticonvulsant effects may depend upon the activation of the A1 receptor.
AB - The present study in rats was designed to identify the respective roles of A1 and A2 adenosine receptor activation in the anticonvulsant and behavioral actions of adenosine. Intracaudate injections of the highly selective A2 agonist, CGS 21680, did not affect caudate seizures. However, seizure threshold was increased in the presence of CGS 21680 after blockade of the A1 receptor with CPX, or following activation of the A1 receptor with R-PIA or NECA. Additionally, CGS 21680 led to a dose-related inhibition of locomotor activity when injected into the caudate. These results implicate the involvement of the A2 adenosine receptor in the locomotor depressant actions of adenosine and also suggest possible A2 anticonvulsant effects may depend upon the activation of the A1 receptor.
KW - Adenosine
KW - Alkylxanthine
KW - Anticonvulsant
KW - Caudate nucleus
KW - Locomotor activity
UR - http://www.scopus.com/inward/record.url?scp=0027328051&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027328051&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(93)90139-K
DO - 10.1016/0091-3057(93)90139-K
M3 - Article
C2 - 8415830
AN - SCOPUS:0027328051
VL - 45
SP - 913
EP - 919
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 4
ER -