Adenosine uptake inhibitors potentiate the sedative effects of adenosine

Jacqueline Crawley, J. Patel, P. J. Marangos

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

A major action of adenosine is the induction of profound behavioral inactivity. 6-(4-Nitrobenzyl)-thioinosine (NBI) and 6-(2-hydroxy-5-nitrobenzyl)-thioguanosine (NBG) have been shown to inhibit adenosine uptake. To investigate the possible synergism between exogenous ligand and reuptake inhibition, mice were treated with NBI or NBG + adenosine. NBI and NBG potentiated the effects of adenosine at doses which did not in themselves induce behavioral inactivity. These behavioral results support the proposed role of NBI and NBG as adenosine uptake site blockers which increase synaptic concentrations of adenosine and postsynaptic responses to adenosine in vivo.

Original languageEnglish (US)
Pages (from-to)169-174
Number of pages6
JournalNeuroscience Letters
Volume36
Issue number2
DOIs
StatePublished - Apr 11 1983
Externally publishedYes

Fingerprint

Hypnotics and Sedatives
Adenosine
Ligands
4-nitrobenzylthioinosine

Keywords

  • adenosine
  • reuptake inhibition
  • sedation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Adenosine uptake inhibitors potentiate the sedative effects of adenosine. / Crawley, Jacqueline; Patel, J.; Marangos, P. J.

In: Neuroscience Letters, Vol. 36, No. 2, 11.04.1983, p. 169-174.

Research output: Contribution to journalArticle

Crawley, Jacqueline ; Patel, J. ; Marangos, P. J. / Adenosine uptake inhibitors potentiate the sedative effects of adenosine. In: Neuroscience Letters. 1983 ; Vol. 36, No. 2. pp. 169-174.
@article{bd9218c57a804c3682ffe6f19ff27389,
title = "Adenosine uptake inhibitors potentiate the sedative effects of adenosine",
abstract = "A major action of adenosine is the induction of profound behavioral inactivity. 6-(4-Nitrobenzyl)-thioinosine (NBI) and 6-(2-hydroxy-5-nitrobenzyl)-thioguanosine (NBG) have been shown to inhibit adenosine uptake. To investigate the possible synergism between exogenous ligand and reuptake inhibition, mice were treated with NBI or NBG + adenosine. NBI and NBG potentiated the effects of adenosine at doses which did not in themselves induce behavioral inactivity. These behavioral results support the proposed role of NBI and NBG as adenosine uptake site blockers which increase synaptic concentrations of adenosine and postsynaptic responses to adenosine in vivo.",
keywords = "adenosine, reuptake inhibition, sedation",
author = "Jacqueline Crawley and J. Patel and Marangos, {P. J.}",
year = "1983",
month = "4",
day = "11",
doi = "10.1016/0304-3940(83)90260-4",
language = "English (US)",
volume = "36",
pages = "169--174",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Adenosine uptake inhibitors potentiate the sedative effects of adenosine

AU - Crawley, Jacqueline

AU - Patel, J.

AU - Marangos, P. J.

PY - 1983/4/11

Y1 - 1983/4/11

N2 - A major action of adenosine is the induction of profound behavioral inactivity. 6-(4-Nitrobenzyl)-thioinosine (NBI) and 6-(2-hydroxy-5-nitrobenzyl)-thioguanosine (NBG) have been shown to inhibit adenosine uptake. To investigate the possible synergism between exogenous ligand and reuptake inhibition, mice were treated with NBI or NBG + adenosine. NBI and NBG potentiated the effects of adenosine at doses which did not in themselves induce behavioral inactivity. These behavioral results support the proposed role of NBI and NBG as adenosine uptake site blockers which increase synaptic concentrations of adenosine and postsynaptic responses to adenosine in vivo.

AB - A major action of adenosine is the induction of profound behavioral inactivity. 6-(4-Nitrobenzyl)-thioinosine (NBI) and 6-(2-hydroxy-5-nitrobenzyl)-thioguanosine (NBG) have been shown to inhibit adenosine uptake. To investigate the possible synergism between exogenous ligand and reuptake inhibition, mice were treated with NBI or NBG + adenosine. NBI and NBG potentiated the effects of adenosine at doses which did not in themselves induce behavioral inactivity. These behavioral results support the proposed role of NBI and NBG as adenosine uptake site blockers which increase synaptic concentrations of adenosine and postsynaptic responses to adenosine in vivo.

KW - adenosine

KW - reuptake inhibition

KW - sedation

UR - http://www.scopus.com/inward/record.url?scp=0020577197&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020577197&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(83)90260-4

DO - 10.1016/0304-3940(83)90260-4

M3 - Article

VL - 36

SP - 169

EP - 174

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -