Addictive substances may induce a rapid neurological deterioration in fragile X-associated tremor ataxia syndrome: A report of two cases

Muzar Zukhrofi, Patrick E. Adams, Schneider Andrea, Randi J Hagerman, Lozano Reymundo

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

A debilitating late-onset disorder of the premutation in the FMR1 gene is the neurodegenerative disorder fragile X-associated tremor ataxia syndrome (FXTAS). We report two patients with FXTAS who have a history of substance abuse (opiates, alcohol, and cocaine) which may have exacerbated their rapid neurological deterioration with FXTAS. There has been no case report regarding the role of substance abuse in onset, progression, and severity of FXTAS symptoms. However, research has shown that substance abuse can have a negative impact on several neurodegenerative diseases, and we propose that in these cases, substance abuse contributed to a faster progression of FXTAS as well as exacerbated white matter disease.

Original languageEnglish (US)
Pages (from-to)162-165
Number of pages4
JournalIntractable and Rare Diseases Research
Volume3
Issue number4
DOIs
StatePublished - 2014

Keywords

  • FXTAS
  • neurological deterioration
  • opiates
  • premutation
  • Substance abuse

ASJC Scopus subject areas

  • Medicine(all)

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