Adaptive optics with combined optical coherence tomography and scanning laser ophthalmoscopy for in vivo mouse retina imaging

Pengfei Zhang, Daniel J. Wahl, Jacopo Mocci, Suman Manna, Ratheesh K. Meleppat, Stefano Bonora, Marinko V. Sarunic, Edward N Pugh Jr, Robert Zawadzki

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO) are two state-of-the-art imaging technologies commonly used to study retina. Adaptive Optics (AO) methodologies enable high-fidelity correction of ocular aberrations, resulting in improved resolution and sensitivity for both SLO and OCT systems. Here we present work integrating OCT into a previously described mouse retinal AO-SLO system, allowing simultaneous reflectance and fluorescence imaging. The new system allows simultaneous data acquisition of AO-SLO and AO-OCT, facilitating registration and comparison of data from both modalities. The system has data acquisition speed of 200 kHz A-scans/pixel, and high volumetric resolution.

Original languageEnglish (US)
Title of host publicationOphthalmic Technologies XXVIII
PublisherSPIE
Volume10474
ISBN (Electronic)9781510614338
DOIs
StatePublished - Jan 1 2018
Event28th Conference on Ophthalmic Technologies - San Francisco, United States
Duration: Jan 27 2018Jan 28 2018

Other

Other28th Conference on Ophthalmic Technologies
CountryUnited States
CitySan Francisco
Period1/27/181/28/18

Keywords

  • Adaptive Optics
  • Multimodal System
  • Optical Coherence Tomography
  • Retinal Imaging
  • Scanning Laser Ophthalmoscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Zhang, P., Wahl, D. J., Mocci, J., Manna, S., Meleppat, R. K., Bonora, S., Sarunic, M. V., Pugh Jr, E. N., & Zawadzki, R. (2018). Adaptive optics with combined optical coherence tomography and scanning laser ophthalmoscopy for in vivo mouse retina imaging. In Ophthalmic Technologies XXVIII (Vol. 10474). [1047427] SPIE. https://doi.org/10.1117/12.2288607