Adaptive optics optical coherence tomography with dynamic retinal tracking

Omer P. Kocaoglu, R. Daniel Ferguson, Ravi Jonnal, Zhuolin Liu, Qiang Wang, Daniel X. Hammer, Donald T. Miller

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Adaptive optics optical coherence tomography (AO-OCT) is a highly sensitive and noninvasive method for three dimensional imaging of the microscopic retina. Like all in vivo retinal imaging techniques, however, it suffers the effects of involuntary eye movements that occur even under normal fixation. In this study we investigated dynamic retinal tracking to measure and correct eye motion at KHz rates for AO-OCT imaging. A customized retina tracking module was integrated into the sample arm of the 2nd-generation Indiana AO-OCT system and images were acquired on three subjects. Analyses were developed based on temporal amplitude and spatial power spectra in conjunction with strip-wise registration to independently measure AO-OCT tracking performance. After optimization of the tracker parameters, the system was found to correct eye movements up to 100 Hz and reduce residual motion to 10 μm root mean square. Between session precision was 33 μm. Performance was limited by trackergenerated noise at high temporal frequencies.

Original languageEnglish (US)
Pages (from-to)2262-2284
Number of pages23
JournalBiomedical Optics Express
Volume5
Issue number7
DOIs
StatePublished - Jun 1 2014

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

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    Kocaoglu, O. P., Ferguson, R. D., Jonnal, R., Liu, Z., Wang, Q., Hammer, D. X., & Miller, D. T. (2014). Adaptive optics optical coherence tomography with dynamic retinal tracking. Biomedical Optics Express, 5(7), 2262-2284. https://doi.org/10.1364/BOE.5.002262