Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging

Robert J. Zawadzki, Steven M. Jones, Scot S. Olivier, Mingtao Zhao, Bradley A. Bower, Joseph A. Izatt, Stacey Choi, Sophie Laut, John S. Werner

Research output: Contribution to journalArticle

350 Scopus citations

Abstract

We have combined Fourier-domain optical coherence tomography (FD-OCT) with a closed-loop adaptive optics (AO) system using a Hartmann-Shack wavefront sensor and a bimorph deformable mirror. The adaptive optics system measures and corrects the wavefront aberration of the human eye for improved lateral resolution (∼4 μm) of retinal images, while maintaining the high axial resolution (∼6 μm) of stand alone OCT. The AO-OCT instrument enables the three-dimensional (3D) visualization of different retinal structures in vivo with high 3D resolution (4×4×6 μm). Using this system, we have demonstrated the ability to image microscopic blood vessels and the cone photoreceptor mosaic.

Original languageEnglish (US)
JournalOptics Express
Volume13
Issue number21
StatePublished - Oct 17 2005

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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    Zawadzki, R. J., Jones, S. M., Olivier, S. S., Zhao, M., Bower, B. A., Izatt, J. A., Choi, S., Laut, S., & Werner, J. S. (2005). Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging. Optics Express, 13(21).