Abstract
We have combined Fourier-domain optical coherence tomography (FD-OCT) with a closed-loop adaptive optics (AO) system using a Hartmann-Shack wavefront sensor and a bimorph deformable mirror. The adaptive optics system measures and corrects the wavefront aberration of the human eye for improved lateral resolution (∼4 μm) of retinal images, while maintaining the high axial resolution (∼6 μm) of stand alone OCT. The AO-OCT instrument enables the three-dimensional (3D) visualization of different retinal structures in vivo with high 3D resolution (4×4×6 μm). Using this system, we have demonstrated the ability to image microscopic blood vessels and the cone photoreceptor mosaic.
| Original language | English (US) |
|---|---|
| Journal | Optics Express |
| Volume | 13 |
| Issue number | 21 |
| State | Published - Oct 17 2005 |
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ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
Cite this
Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging. / Zawadzki, Robert; Jones, Steven M.; Olivier, Scot S.; Zhao, Mingtao; Bower, Bradley A.; Izatt, Joseph A.; Choi, Stacey; Werner, John S; Werner, John S.
In: Optics Express, Vol. 13, No. 21, 17.10.2005.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging
AU - Zawadzki, Robert
AU - Jones, Steven M.
AU - Olivier, Scot S.
AU - Zhao, Mingtao
AU - Bower, Bradley A.
AU - Izatt, Joseph A.
AU - Choi, Stacey
AU - Werner, John S
AU - Werner, John S.
PY - 2005/10/17
Y1 - 2005/10/17
N2 - We have combined Fourier-domain optical coherence tomography (FD-OCT) with a closed-loop adaptive optics (AO) system using a Hartmann-Shack wavefront sensor and a bimorph deformable mirror. The adaptive optics system measures and corrects the wavefront aberration of the human eye for improved lateral resolution (∼4 μm) of retinal images, while maintaining the high axial resolution (∼6 μm) of stand alone OCT. The AO-OCT instrument enables the three-dimensional (3D) visualization of different retinal structures in vivo with high 3D resolution (4×4×6 μm). Using this system, we have demonstrated the ability to image microscopic blood vessels and the cone photoreceptor mosaic.
AB - We have combined Fourier-domain optical coherence tomography (FD-OCT) with a closed-loop adaptive optics (AO) system using a Hartmann-Shack wavefront sensor and a bimorph deformable mirror. The adaptive optics system measures and corrects the wavefront aberration of the human eye for improved lateral resolution (∼4 μm) of retinal images, while maintaining the high axial resolution (∼6 μm) of stand alone OCT. The AO-OCT instrument enables the three-dimensional (3D) visualization of different retinal structures in vivo with high 3D resolution (4×4×6 μm). Using this system, we have demonstrated the ability to image microscopic blood vessels and the cone photoreceptor mosaic.
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UR - http://www.scopus.com/inward/citedby.url?scp=26844495794&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:26844495794
VL - 13
JO - Optics Express
JF - Optics Express
SN - 1094-4087
IS - 21
ER -