Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging

Robert Zawadzki, Steven M. Jones, Scot S. Olivier, Mingtao Zhao, Bradley A. Bower, Joseph A. Izatt, Stacey Choi, John S Werner, John S. Werner

Research output: Contribution to journalArticle

345 Citations (Scopus)

Abstract

We have combined Fourier-domain optical coherence tomography (FD-OCT) with a closed-loop adaptive optics (AO) system using a Hartmann-Shack wavefront sensor and a bimorph deformable mirror. The adaptive optics system measures and corrects the wavefront aberration of the human eye for improved lateral resolution (∼4 μm) of retinal images, while maintaining the high axial resolution (∼6 μm) of stand alone OCT. The AO-OCT instrument enables the three-dimensional (3D) visualization of different retinal structures in vivo with high 3D resolution (4×4×6 μm). Using this system, we have demonstrated the ability to image microscopic blood vessels and the cone photoreceptor mosaic.

Original languageEnglish (US)
JournalOptics Express
Volume13
Issue number21
StatePublished - Oct 17 2005

Fingerprint

adaptive optics
tomography
high speed
high resolution
retinal images
photoreceptors
deformable mirrors
blood vessels
aberration
cones
sensors

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Zawadzki, R., Jones, S. M., Olivier, S. S., Zhao, M., Bower, B. A., Izatt, J. A., ... Werner, J. S. (2005). Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging. Optics Express, 13(21).

Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging. / Zawadzki, Robert; Jones, Steven M.; Olivier, Scot S.; Zhao, Mingtao; Bower, Bradley A.; Izatt, Joseph A.; Choi, Stacey; Werner, John S; Werner, John S.

In: Optics Express, Vol. 13, No. 21, 17.10.2005.

Research output: Contribution to journalArticle

Zawadzki, R, Jones, SM, Olivier, SS, Zhao, M, Bower, BA, Izatt, JA, Choi, S, Werner, JS & Werner, JS 2005, 'Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging', Optics Express, vol. 13, no. 21.
Zawadzki, Robert ; Jones, Steven M. ; Olivier, Scot S. ; Zhao, Mingtao ; Bower, Bradley A. ; Izatt, Joseph A. ; Choi, Stacey ; Werner, John S ; Werner, John S. / Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging. In: Optics Express. 2005 ; Vol. 13, No. 21.
@article{3d41c18b42a744b48649669130b03128,
title = "Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging",
abstract = "We have combined Fourier-domain optical coherence tomography (FD-OCT) with a closed-loop adaptive optics (AO) system using a Hartmann-Shack wavefront sensor and a bimorph deformable mirror. The adaptive optics system measures and corrects the wavefront aberration of the human eye for improved lateral resolution (∼4 μm) of retinal images, while maintaining the high axial resolution (∼6 μm) of stand alone OCT. The AO-OCT instrument enables the three-dimensional (3D) visualization of different retinal structures in vivo with high 3D resolution (4×4×6 μm). Using this system, we have demonstrated the ability to image microscopic blood vessels and the cone photoreceptor mosaic.",
author = "Robert Zawadzki and Jones, {Steven M.} and Olivier, {Scot S.} and Mingtao Zhao and Bower, {Bradley A.} and Izatt, {Joseph A.} and Stacey Choi and Werner, {John S} and Werner, {John S.}",
year = "2005",
month = "10",
day = "17",
language = "English (US)",
volume = "13",
journal = "Optics Express",
issn = "1094-4087",
publisher = "The Optical Society",
number = "21",

}

TY - JOUR

T1 - Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging

AU - Zawadzki, Robert

AU - Jones, Steven M.

AU - Olivier, Scot S.

AU - Zhao, Mingtao

AU - Bower, Bradley A.

AU - Izatt, Joseph A.

AU - Choi, Stacey

AU - Werner, John S

AU - Werner, John S.

PY - 2005/10/17

Y1 - 2005/10/17

N2 - We have combined Fourier-domain optical coherence tomography (FD-OCT) with a closed-loop adaptive optics (AO) system using a Hartmann-Shack wavefront sensor and a bimorph deformable mirror. The adaptive optics system measures and corrects the wavefront aberration of the human eye for improved lateral resolution (∼4 μm) of retinal images, while maintaining the high axial resolution (∼6 μm) of stand alone OCT. The AO-OCT instrument enables the three-dimensional (3D) visualization of different retinal structures in vivo with high 3D resolution (4×4×6 μm). Using this system, we have demonstrated the ability to image microscopic blood vessels and the cone photoreceptor mosaic.

AB - We have combined Fourier-domain optical coherence tomography (FD-OCT) with a closed-loop adaptive optics (AO) system using a Hartmann-Shack wavefront sensor and a bimorph deformable mirror. The adaptive optics system measures and corrects the wavefront aberration of the human eye for improved lateral resolution (∼4 μm) of retinal images, while maintaining the high axial resolution (∼6 μm) of stand alone OCT. The AO-OCT instrument enables the three-dimensional (3D) visualization of different retinal structures in vivo with high 3D resolution (4×4×6 μm). Using this system, we have demonstrated the ability to image microscopic blood vessels and the cone photoreceptor mosaic.

UR - http://www.scopus.com/inward/record.url?scp=26844495794&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26844495794&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:26844495794

VL - 13

JO - Optics Express

JF - Optics Express

SN - 1094-4087

IS - 21

ER -