Abstract
The AM model is consistent with a large body of experimental data obtained by others (10, 39) and is supported by additional experiments designed to test it more directly (2, 16, 21). This model explains how growth under selection can increase the probability of selected mutationsby adding copies of the mutational target. The observed general mutagenesis is explained as a nonessential side effect due to occasional coamplification of lac with the nearby dinB+ gene. We suggest the Cairns-Foster system has made a major contribution by revealing a genetic mechanism by which growth under strong selection can enhance production of adaptive mutations without changing either the rate or target specificity of mutation. Because AM relies on standard genetic events, it is likely to operate in any organism and contribute to genetic adaptation in many biological situations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4855-4860 |
| Number of pages | 6 |
| Journal | Journal of Bacteriology |
| Volume | 186 |
| Issue number | 15 |
| DOIs | |
| State | Published - Aug 2004 |
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ASJC Scopus subject areas
- Applied Microbiology and Biotechnology
- Immunology
Cite this
Adaptive mutation : How growth under selection stimulates Lac+ reversion by increasing target copy number. / Roth, John R.; Andersson, Dan I.
In: Journal of Bacteriology, Vol. 186, No. 15, 08.2004, p. 4855-4860.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adaptive mutation
T2 - How growth under selection stimulates Lac+ reversion by increasing target copy number
AU - Roth, John R.
AU - Andersson, Dan I.
PY - 2004/8
Y1 - 2004/8
N2 - The AM model is consistent with a large body of experimental data obtained by others (10, 39) and is supported by additional experiments designed to test it more directly (2, 16, 21). This model explains how growth under selection can increase the probability of selected mutationsby adding copies of the mutational target. The observed general mutagenesis is explained as a nonessential side effect due to occasional coamplification of lac with the nearby dinB+ gene. We suggest the Cairns-Foster system has made a major contribution by revealing a genetic mechanism by which growth under strong selection can enhance production of adaptive mutations without changing either the rate or target specificity of mutation. Because AM relies on standard genetic events, it is likely to operate in any organism and contribute to genetic adaptation in many biological situations.
AB - The AM model is consistent with a large body of experimental data obtained by others (10, 39) and is supported by additional experiments designed to test it more directly (2, 16, 21). This model explains how growth under selection can increase the probability of selected mutationsby adding copies of the mutational target. The observed general mutagenesis is explained as a nonessential side effect due to occasional coamplification of lac with the nearby dinB+ gene. We suggest the Cairns-Foster system has made a major contribution by revealing a genetic mechanism by which growth under strong selection can enhance production of adaptive mutations without changing either the rate or target specificity of mutation. Because AM relies on standard genetic events, it is likely to operate in any organism and contribute to genetic adaptation in many biological situations.
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UR - http://www.scopus.com/inward/citedby.url?scp=3242742140&partnerID=8YFLogxK
U2 - 10.1128/JB.186.15.4855-4860.2004
DO - 10.1128/JB.186.15.4855-4860.2004
M3 - Article
VL - 186
SP - 4855
EP - 4860
JO - Journal of Bacteriology
JF - Journal of Bacteriology
SN - 0021-9193
IS - 15
ER -