Adaptive functioning in children and adolescents with Trisomy X: An exploratory analysis

Kristen Wigby, Lisa Cordeiro, Rebecca Wilson, Kathleen Angkustsiri, Tony J. Simon, Nicole Tartaglia

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Identifying the factors related to adaptive functioning will improve the information available to families and providers of females with Trisomy X. Cognitive and behavioral features were assessed in 50 females ages 12.2 ± 3.6 years using the Behavior Assessment System for Children Second Edition (BASC-2) and Wechsler Scales of Intelligence. Executive functioning, social skills, and autistic traits were evaluated in a subset. Adaptive functioning was assessed using the BASC-2 adaptive skills composite score (ASC). Participants were classified as average adaptive skills (ASC T-score > 40) or deficits (ASC T-score < 40). Group comparisons were conducted. Multiple linear regression examined which factors contributed to ASC score. Twenty-eight females (55.6%) had adaptive skills deficits with functional communication being the most commonly affected adaptive domain. The group with ASC in the average range had higher verbal IQ (VIQ) and lower rates of numerous behavioral concerns. Internalizing behavior composite, DSM-IV inattentive symptoms score, and VIQ were significant predictors of ASC. Prenatally diagnosed females comprised over 70% of those with average adaptive skills. In this study, internalizing behaviors, inattentive ADHD symptoms, and VIQ were associated with poorer adaptive functioning. Early interventions targeting internalizing behaviors, attention/executive functioning, and communication skills may improve adaptive skills and deserve further study.

Original languageEnglish (US)
Pages (from-to)456-468
Number of pages13
JournalAmerican Journal of Medical Genetics, Part C: Seminars in Medical Genetics
Issue number2
StatePublished - Jun 1 2020


  • adaptive skills
  • inattention
  • prenatal
  • Triple X syndrome
  • Trisomy X

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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