Adaptation to cognitive context and item information in the medial temporal lobes

Rachel A. Diana, Andrew P. Yonelinas, Charan Ranganath

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The medial temporal lobes (MTL) play an essential role in episodic memory, and accumulating evidence indicates that two MTL subregions-the perirhinal (PRc) and parahippocampal (PHc) cortices-might have different functions. According to the binding of item and context theory (Diana, Yonelinas, & Ranganath, 2007; Eichenbaum, Yonelinas, & Ranganath, 2007), PRc is involved in processing item information, the target of memory encoding, whereas PHc is involved in processing context information, peripheral information that identifies the circumstances of the episode. Here, we used functional magnetic resonance imaging (fMRI) adaptation to test the roles of different MTL subregions in the processing of item and context information. Participants were scanned while viewing a series of objects. Each object was presented with a unique semantic encoding question that elicited a salient cognitive context. The object picture, the encoding question, both, or neither were immediately repeated. We found that PRc activity was sensitive to repetition of the object but not the encoding question whereas PHc activity was sensitive to repetition of the encoding question but not the object. These data are consistent with the idea that the PRc and PHc are differentially involved in the representation of item and context information and additionally suggest that the role of the PHc extends to nonspatial, cognitive context information.

Original languageEnglish (US)
Pages (from-to)3062-3069
Number of pages8
JournalNeuropsychologia
Volume50
Issue number13
DOIs
StatePublished - Nov 2012

Fingerprint

Temporal Lobe
Automatic Data Processing
Episodic Memory
Semantics
Magnetic Resonance Imaging
Medial Temporal Lobe
Encoding

Keywords

  • Adaptation
  • Context
  • Memory
  • Parahippocampal cortex
  • Perirhinal cortex

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology
  • Arts and Humanities (miscellaneous)

Cite this

Adaptation to cognitive context and item information in the medial temporal lobes. / Diana, Rachel A.; Yonelinas, Andrew P.; Ranganath, Charan.

In: Neuropsychologia, Vol. 50, No. 13, 11.2012, p. 3062-3069.

Research output: Contribution to journalArticle

Diana, Rachel A. ; Yonelinas, Andrew P. ; Ranganath, Charan. / Adaptation to cognitive context and item information in the medial temporal lobes. In: Neuropsychologia. 2012 ; Vol. 50, No. 13. pp. 3062-3069.
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