Adaptation of lipid-induced satiation is not dependent on caloric density in rats

G. Paulino, N. Darcel, D. Tome, Helen E Raybould

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Food intake is modulated by ingestive (gastrointestinal) and post-ingestive signals; ingested fat is potent to produce short-term satiety (satiation) but this can be modified by long-term ingestion of a high fat diet. Aim: Determine whether altered lipid-induced satiation is dependent on the fat content of the diet, rather than increased caloric density or changes in adiposity. Methods: Initial experiments determined the differences in the microstructure of meal patterns in rats fed a high fat diet (HF: 38% fat kcal) and in rats pair-fed an isocaloric, isonitrogenous low fat diet (LF: 10% fat kcal) and changes in meal patterns measured after long-term maintenance on the HF diet. Results: Rats fed the HF diet had a significant 50% increase in meal frequency compared to rats fed the LF diet; in addition, there was a significant reduction in meal size (32%) and inter meal interval (38%) consistent with induction of satiation. After 8 weeks on the HF diet, these parameters tend to approach those of rats maintained on the LF diet. There was a significant 56% decrease in the activation of neurons in the NTS in response to intragastric gavage of lipid in rats maintained for 8 weeks on the HF compared to LF diet. Conclusion: Dietary fat alters meal patterns consistent with induction of a short-term satiety signal. This signal is attenuated with long-term exposure to dietary lipid, in the absence of ingestion of additional calories or changes in body weight. This adaptation of short-term satiety might contribute to diet-induced obesity.

Original languageEnglish (US)
Pages (from-to)930-936
Number of pages7
JournalPhysiology and Behavior
Issue number4-5
StatePublished - Mar 18 2008


  • Diet adaptation
  • Food intake
  • High fat
  • Meal pattern analysis
  • Satiation

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Physiology (medical)


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