ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11

Katy E. Georgiadis, Satoshi Hirohata, Michael F Seldin, Suneel S. Apte

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A disintegrin-like and metalloprotease domain with thrombospondin type I modules (ADAM-TS) describes a novel family of zinc metalloendopeptidases. Its members have a common domain organization, which includes, typically, a pre- pro-metalloprotease domain, a disintegrin-like domain, and one or more thrombospondin-like (TS) modules. We describe here the complete primary structure of mouse ADAM-TS8, through cloning of Adamts8 cDNA. This novel member of the family contains two TS modules and is highly similar in sequence and domain organization to three other recently described gene products, ADAM-TS5, ADAM-TS6, and ADAM-TS7. Adamts8 is expressed at low levels throughout development and in adult mouse lung and heart. Through analysis of an interspecific backcross panel, we place the Adamts8 locus on mouse chromosome 9 at a consensus position of 11 cM and its human ortholog, recently reported as the METH2 gene, on human chromosome 11q25.

Original languageEnglish (US)
Pages (from-to)312-315
Number of pages4
JournalGenomics
Volume62
Issue number2
DOIs
StatePublished - Dec 1 1999

Fingerprint

Thrombospondins
Chromosomes, Human, Pair 9
Chromosomes, Human, Pair 11
Human Chromosomes
Metalloproteases
Disintegrins
Metalloendopeptidases
Genes
Zinc
Organism Cloning
Consensus
Complementary DNA
Lung

ASJC Scopus subject areas

  • Genetics

Cite this

ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11. / Georgiadis, Katy E.; Hirohata, Satoshi; Seldin, Michael F; Apte, Suneel S.

In: Genomics, Vol. 62, No. 2, 01.12.1999, p. 312-315.

Research output: Contribution to journalArticle

Georgiadis, Katy E. ; Hirohata, Satoshi ; Seldin, Michael F ; Apte, Suneel S. / ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11. In: Genomics. 1999 ; Vol. 62, No. 2. pp. 312-315.
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