Acute toxicity and developmental effects of analogues of ethyl α-(4-chlorophenoxy)-α-methylpropionate on two insects, Oncopeltus fasciatus and Tenebrio molitor

Bruce D. Hammock, Eiichi Kuwano, Albert Ketterman, Rudolf H. Scheffrahn, S. N. Thompson, Debora Sallume

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Forty analogues of the hypocholesterolemic agent clofibrate were synthesized and bioassayed on the yellow mealworm, Tenebrio molitor, and the large milkweed bug, Oncopeltus fasciatus. The compounds demonstrated only weak morphogenic activity in T. molitor but moderate acute toxicity in O. fasciatus. The acute symptoms of clofibrate analogues in O. fasciatus were similar to those induced by the antijuvenile hormone precocene. Clofibrate analogues resulted in delayed or blocked development of O. fasciatus nymphs, yet failed to produce clear antijuvenile hormone activity.

Original languageEnglish (US)
Pages (from-to)166-170
Number of pages5
JournalJournal of Agricultural and Food Chemistry
Volume26
Issue number1
StatePublished - 1978

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Food Science
  • Chemistry (miscellaneous)

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