Acute Rhabdomyolysis Associated with Cocaine Intoxication

Ramkrishna Kothur, Gerald L. Posner, Anne A Knowlton, Cecelia Hard, Barry Herzlich, Edward Arsura, Murali Pagala, David Grob, David Roth, Jacques J. Bourgoignie

Research output: Contribution to journalLetterpeer-review

9 Scopus citations


To the Editor: In the article entitled “Acute Rhabdomyolysis Associated with Cocaine Intoxication” (Sept. 15 issue),* Dr. Roth and his colleagues reported 11 cases of hepatic dysfunction in 13 patients with renal failure. Six of the 11 patients were hypotensive on admission. Two patients without renal failure also had hepatic dysfunction, but concomitant hypotension was not mentioned. Roth et al. consider that hypotension may be partly responsible for hepatic dysfunction. They did not report the time course of the hepatic enzyme abnormalities. In “shock liver,” the enzyme levels increase dramatically, with rapid normalization within a few days once hypotension is…

Original languageEnglish (US)
Pages (from-to)667-668
Number of pages2
JournalNew England Journal of Medicine
Issue number10
StatePublished - Mar 9 1989
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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