Acute Rhabdomyolysis Associated with Cocaine Intoxication

Ramkrishna Kothur; Gerald L. Posner; Anne A Knowlton; Cecelia Hard; Barry Herzlich; Edward Arsura; Murali Pagala; David Grob; David Roth; Jacques J. Bourgoignie

doi:10.1056/NEJM198903093201011

Acute Rhabdomyolysis Associated with Cocaine Intoxication

Ramkrishna Kothur, Gerald L. Posner, Anne A Knowlton, Cecelia Hard, Barry Herzlich, Edward Arsura, Murali Pagala, David Grob, David Roth, Jacques J. Bourgoignie

Research output: Contribution to journal › Letter

8 Scopus citations

Abstract

To the Editor: In the article entitled “Acute Rhabdomyolysis Associated with Cocaine Intoxication” (Sept. 15 issue),* Dr. Roth and his colleagues reported 11 cases of hepatic dysfunction in 13 patients with renal failure. Six of the 11 patients were hypotensive on admission. Two patients without renal failure also had hepatic dysfunction, but concomitant hypotension was not mentioned. Roth et al. consider that hypotension may be partly responsible for hepatic dysfunction. They did not report the time course of the hepatic enzyme abnormalities. In “shock liver,” the enzyme levels increase dramatically, with rapid normalization within a few days once hypotension is…

Original language	English (US)
Pages (from-to)	667-668
Number of pages	2
Journal	New England Journal of Medicine
Volume	320
Issue number	10
DOIs	https://doi.org/10.1056/NEJM198903093201011
State	Published - Mar 9 1989
Externally published	Yes

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Medicine(all)

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Kothur, R., Posner, G. L., Knowlton, A. A., Hard, C., Herzlich, B., Arsura, E., Pagala, M., Grob, D., Roth, D., & Bourgoignie, J. J. (1989). Acute Rhabdomyolysis Associated with Cocaine Intoxication. New England Journal of Medicine, 320(10), 667-668. https://doi.org/10.1056/NEJM198903093201011

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abstract = "To the Editor: In the article entitled “Acute Rhabdomyolysis Associated with Cocaine Intoxication” (Sept. 15 issue),* Dr. Roth and his colleagues reported 11 cases of hepatic dysfunction in 13 patients with renal failure. Six of the 11 patients were hypotensive on admission. Two patients without renal failure also had hepatic dysfunction, but concomitant hypotension was not mentioned. Roth et al. consider that hypotension may be partly responsible for hepatic dysfunction. They did not report the time course of the hepatic enzyme abnormalities. In “shock liver,” the enzyme levels increase dramatically, with rapid normalization within a few days once hypotension is…",

author = "Ramkrishna Kothur and Posner, {Gerald L.} and Knowlton, {Anne A} and Cecelia Hard and Barry Herzlich and Edward Arsura and Murali Pagala and David Grob and David Roth and Bourgoignie, {Jacques J.}",

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AU - Kothur, Ramkrishna

AU - Posner, Gerald L.

AU - Knowlton, Anne A

AU - Hard, Cecelia

AU - Herzlich, Barry

AU - Arsura, Edward

AU - Pagala, Murali

AU - Grob, David

AU - Roth, David

AU - Bourgoignie, Jacques J.

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AB - To the Editor: In the article entitled “Acute Rhabdomyolysis Associated with Cocaine Intoxication” (Sept. 15 issue),* Dr. Roth and his colleagues reported 11 cases of hepatic dysfunction in 13 patients with renal failure. Six of the 11 patients were hypotensive on admission. Two patients without renal failure also had hepatic dysfunction, but concomitant hypotension was not mentioned. Roth et al. consider that hypotension may be partly responsible for hepatic dysfunction. They did not report the time course of the hepatic enzyme abnormalities. In “shock liver,” the enzyme levels increase dramatically, with rapid normalization within a few days once hypotension is…

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10.1056/NEJM198903093201011