Acute phase proteins in naturally occurring respiratory disease of feedlot cattle

Ignacio Idoate, Brian Vander Ley, Loren Schultz, Meera C Heller

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The aim of this study was to evaluate three acute phase proteins (APP) [haptoglobin (HPT), lipopolysaccharide binding protein (LBP) and transferrin (Tf)] in feedlot cattle with naturally occurring respiratory disease diagnosed by a calf health scoring chart (CHSC). Seventy-seven beef calves were observed for signs of Bovine Respiratory Disease (BRD) during the first 28 days after arrival at the feedlot. Fourteen cases and pen matched controls were selected based on the CHSC. BRD cases were defined as a score of ≥5, while controls were defined as a score ≤4. The mean CHSC score in cases was 6.9 which was significantly greater than the controls 2.8 (P<. 0.01). Mean plasma LBP and HPT concentrations were significantly greater in cases than controls (P<. 0.01). Our study results show that measurement of HPT and LBP could be useful in detecting respiratory disease in feedlot conditions. Transferrin concentrations between the two groups were not statistically different.

Original languageEnglish (US)
Pages (from-to)221-226
Number of pages6
JournalVeterinary Immunology and Immunopathology
Issue number3-4
StatePublished - Feb 15 2015
Externally publishedYes


  • Acute phase proteins
  • Bovine respiratory disease
  • Haptoglobin
  • Lipopolysaccharide binding protein
  • Transferrin

ASJC Scopus subject areas

  • Immunology
  • veterinary(all)
  • Medicine(all)


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