Abstract
Twenty O3-sensitive and 2O O3-nonsensitive subjects participated in a study to investigate the effects of disparate O3 sensitivity on plasma prostaglandin F(2α) (PGF(2α)) responses consequent to exposure to ambient O3 concentrations. Subjects were selected from a pool of 75 normal healthy college-aged males who had been previously exposed to 0.35 ppm O3 for 1 h at an exercising V̇E of 60 L/min. The selection criterion used was the observed decrement in FEV1 after the O3 exposure: O3-sensitive, FEV1 decrement >24%; O3-nonsensitive, FEV1 decrement <11%. Each subject was exposed to filtered air and to 0.20 and 0.35 ppm O3 for 80 min while exercising at a V̇E of 50 L/min. These experimental protocols were divided into two 40-min sessions separated by a period of 4 to 10 min. PGF(2α), FVC, FEV1, and FEF25-75 were evaluated before, during, and after each protocol. S(Gaw) and V(tg) were measured before and after each protocol. Plasma PGF(2α) was significantly increased in the O3-sensitive group during and after the 0.35-ppm O3 exposure.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 211-216 |
| Number of pages | 6 |
| Journal | American Review of Respiratory Disease |
| Volume | 140 |
| Issue number | 1 |
| State | Published - 1989 |
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ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Acute ozone exposure increases plasma prostaglandin F(2α) in ozone-sensivitive human subjects. / Schelegle, Edward S; Adams, W. C.; Giri, S. N.; Siefkin, A. D.
In: American Review of Respiratory Disease, Vol. 140, No. 1, 1989, p. 211-216.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute ozone exposure increases plasma prostaglandin F(2α) in ozone-sensivitive human subjects
AU - Schelegle, Edward S
AU - Adams, W. C.
AU - Giri, S. N.
AU - Siefkin, A. D.
PY - 1989
Y1 - 1989
N2 - Twenty O3-sensitive and 2O O3-nonsensitive subjects participated in a study to investigate the effects of disparate O3 sensitivity on plasma prostaglandin F(2α) (PGF(2α)) responses consequent to exposure to ambient O3 concentrations. Subjects were selected from a pool of 75 normal healthy college-aged males who had been previously exposed to 0.35 ppm O3 for 1 h at an exercising V̇E of 60 L/min. The selection criterion used was the observed decrement in FEV1 after the O3 exposure: O3-sensitive, FEV1 decrement >24%; O3-nonsensitive, FEV1 decrement <11%. Each subject was exposed to filtered air and to 0.20 and 0.35 ppm O3 for 80 min while exercising at a V̇E of 50 L/min. These experimental protocols were divided into two 40-min sessions separated by a period of 4 to 10 min. PGF(2α), FVC, FEV1, and FEF25-75 were evaluated before, during, and after each protocol. S(Gaw) and V(tg) were measured before and after each protocol. Plasma PGF(2α) was significantly increased in the O3-sensitive group during and after the 0.35-ppm O3 exposure.
AB - Twenty O3-sensitive and 2O O3-nonsensitive subjects participated in a study to investigate the effects of disparate O3 sensitivity on plasma prostaglandin F(2α) (PGF(2α)) responses consequent to exposure to ambient O3 concentrations. Subjects were selected from a pool of 75 normal healthy college-aged males who had been previously exposed to 0.35 ppm O3 for 1 h at an exercising V̇E of 60 L/min. The selection criterion used was the observed decrement in FEV1 after the O3 exposure: O3-sensitive, FEV1 decrement >24%; O3-nonsensitive, FEV1 decrement <11%. Each subject was exposed to filtered air and to 0.20 and 0.35 ppm O3 for 80 min while exercising at a V̇E of 50 L/min. These experimental protocols were divided into two 40-min sessions separated by a period of 4 to 10 min. PGF(2α), FVC, FEV1, and FEF25-75 were evaluated before, during, and after each protocol. S(Gaw) and V(tg) were measured before and after each protocol. Plasma PGF(2α) was significantly increased in the O3-sensitive group during and after the 0.35-ppm O3 exposure.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024381989&partnerID=8YFLogxK
M3 - Article
C2 - 2751167
AN - SCOPUS:0024381989
VL - 140
SP - 211
EP - 216
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
SN - 1073-449X
IS - 1
ER -