Acute ozone exposure increases plasma prostaglandin F(2α) in ozone-sensivitive human subjects

Edward S Schelegle; W. C. Adams; S. N. Giri; A. D. Siefkin

Acute ozone exposure increases plasma prostaglandin F(2α) in ozone-sensivitive human subjects

Edward S Schelegle, W. C. Adams, S. N. Giri, A. D. Siefkin

Anatomy, Physiology and Cell Biology

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Twenty O₃-sensitive and 2O O₃-nonsensitive subjects participated in a study to investigate the effects of disparate O₃ sensitivity on plasma prostaglandin F(2α) (PGF(2α)) responses consequent to exposure to ambient O₃ concentrations. Subjects were selected from a pool of 75 normal healthy college-aged males who had been previously exposed to 0.35 ppm O₃ for 1 h at an exercising V̇E of 60 L/min. The selection criterion used was the observed decrement in FEV₁ after the O₃ exposure: O₃-sensitive, FEV₁ decrement >24%; O₃-nonsensitive, FEV₁ decrement <11%. Each subject was exposed to filtered air and to 0.20 and 0.35 ppm O₃ for 80 min while exercising at a V̇E of 50 L/min. These experimental protocols were divided into two 40-min sessions separated by a period of 4 to 10 min. PGF(2α), FVC, FEV₁, and FEF_25-75 were evaluated before, during, and after each protocol. S(Gaw) and V(tg) were measured before and after each protocol. Plasma PGF(2α) was significantly increased in the O₃-sensitive group during and after the 0.35-ppm O₃ exposure.

Original language	English (US)
Pages (from-to)	211-216
Number of pages	6
Journal	American Review of Respiratory Disease
Volume	140
Issue number	1
State	Published - 1989

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

Cite this

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title = "Acute ozone exposure increases plasma prostaglandin F(2α) in ozone-sensivitive human subjects",

abstract = "Twenty O3-sensitive and 2O O3-nonsensitive subjects participated in a study to investigate the effects of disparate O3 sensitivity on plasma prostaglandin F(2α) (PGF(2α)) responses consequent to exposure to ambient O3 concentrations. Subjects were selected from a pool of 75 normal healthy college-aged males who had been previously exposed to 0.35 ppm O3 for 1 h at an exercising {\.V}E of 60 L/min. The selection criterion used was the observed decrement in FEV1 after the O3 exposure: O3-sensitive, FEV1 decrement >24%; O3-nonsensitive, FEV1 decrement <11%. Each subject was exposed to filtered air and to 0.20 and 0.35 ppm O3 for 80 min while exercising at a {\.V}E of 50 L/min. These experimental protocols were divided into two 40-min sessions separated by a period of 4 to 10 min. PGF(2α), FVC, FEV1, and FEF25-75 were evaluated before, during, and after each protocol. S(Gaw) and V(tg) were measured before and after each protocol. Plasma PGF(2α) was significantly increased in the O3-sensitive group during and after the 0.35-ppm O3 exposure.",

author = "Schelegle, {Edward S} and Adams, {W. C.} and Giri, {S. N.} and Siefkin, {A. D.}",

year = "1989",

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AU - Schelegle, Edward S

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AU - Giri, S. N.

AU - Siefkin, A. D.

PY - 1989

Y1 - 1989

N2 - Twenty O3-sensitive and 2O O3-nonsensitive subjects participated in a study to investigate the effects of disparate O3 sensitivity on plasma prostaglandin F(2α) (PGF(2α)) responses consequent to exposure to ambient O3 concentrations. Subjects were selected from a pool of 75 normal healthy college-aged males who had been previously exposed to 0.35 ppm O3 for 1 h at an exercising V̇E of 60 L/min. The selection criterion used was the observed decrement in FEV1 after the O3 exposure: O3-sensitive, FEV1 decrement >24%; O3-nonsensitive, FEV1 decrement <11%. Each subject was exposed to filtered air and to 0.20 and 0.35 ppm O3 for 80 min while exercising at a V̇E of 50 L/min. These experimental protocols were divided into two 40-min sessions separated by a period of 4 to 10 min. PGF(2α), FVC, FEV1, and FEF25-75 were evaluated before, during, and after each protocol. S(Gaw) and V(tg) were measured before and after each protocol. Plasma PGF(2α) was significantly increased in the O3-sensitive group during and after the 0.35-ppm O3 exposure.

AB - Twenty O3-sensitive and 2O O3-nonsensitive subjects participated in a study to investigate the effects of disparate O3 sensitivity on plasma prostaglandin F(2α) (PGF(2α)) responses consequent to exposure to ambient O3 concentrations. Subjects were selected from a pool of 75 normal healthy college-aged males who had been previously exposed to 0.35 ppm O3 for 1 h at an exercising V̇E of 60 L/min. The selection criterion used was the observed decrement in FEV1 after the O3 exposure: O3-sensitive, FEV1 decrement >24%; O3-nonsensitive, FEV1 decrement <11%. Each subject was exposed to filtered air and to 0.20 and 0.35 ppm O3 for 80 min while exercising at a V̇E of 50 L/min. These experimental protocols were divided into two 40-min sessions separated by a period of 4 to 10 min. PGF(2α), FVC, FEV1, and FEF25-75 were evaluated before, during, and after each protocol. S(Gaw) and V(tg) were measured before and after each protocol. Plasma PGF(2α) was significantly increased in the O3-sensitive group during and after the 0.35-ppm O3 exposure.

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Acute ozone exposure increases plasma prostaglandin F(2α) in ozone-sensivitive human subjects

Abstract

ASJC Scopus subject areas

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