Acute ozone exposure increases plasma prostaglandin F(2α) in ozone-sensivitive human subjects

Edward S Schelegle, W. C. Adams, S. N. Giri, A. D. Siefkin

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Twenty O3-sensitive and 2O O3-nonsensitive subjects participated in a study to investigate the effects of disparate O3 sensitivity on plasma prostaglandin F(2α) (PGF(2α)) responses consequent to exposure to ambient O3 concentrations. Subjects were selected from a pool of 75 normal healthy college-aged males who had been previously exposed to 0.35 ppm O3 for 1 h at an exercising V̇E of 60 L/min. The selection criterion used was the observed decrement in FEV1 after the O3 exposure: O3-sensitive, FEV1 decrement >24%; O3-nonsensitive, FEV1 decrement <11%. Each subject was exposed to filtered air and to 0.20 and 0.35 ppm O3 for 80 min while exercising at a V̇E of 50 L/min. These experimental protocols were divided into two 40-min sessions separated by a period of 4 to 10 min. PGF(2α), FVC, FEV1, and FEF25-75 were evaluated before, during, and after each protocol. S(Gaw) and V(tg) were measured before and after each protocol. Plasma PGF(2α) was significantly increased in the O3-sensitive group during and after the 0.35-ppm O3 exposure.

Original languageEnglish (US)
Pages (from-to)211-216
Number of pages6
JournalAmerican Review of Respiratory Disease
Issue number1
StatePublished - 1989

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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