Acute oral manganese administration does not consistently affect glucose tolerance in non-diabetic and type II diabetic humans

R. M. Walter, T. T. Aoki, Carl L Keen

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

A hypoglycemic effect of manganese has been demonstrated in several species including humans. In this study, we evaluated the effect of acute oral administration of manganese on glucose tolerance and oxidation in six type II diabetic and seven non-diabetic subjects. Subjects were given 1 g/kg BW glucose p.o. with and without 15 and/or 30 mg manganese (as gluconate). Non-diabetic subjects demonstrated brisk insulin and C-peptide responses to glucose accompanied by prompt, complete suppression of glucagon. Type II diabetic subjects showed markedly impaired glucose tolerance, delayed insulin and C-peptide responses, and only minimal inconsistent suppression of pancreatic glucagon. Neither glycemic nor hormonal responses were altered by manganese in either group. These results do not support a generalized effect of acute manganese supplementation on glucose metabolism in either control or type II diabetic subjects.

Original languageEnglish (US)
Pages (from-to)73-79
Number of pages7
JournalJournal of Trace Elements in Experimental Medicine
Volume4
Issue number2
StatePublished - 1991

ASJC Scopus subject areas

  • Biochemistry

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