Acute Optic Neuropathy: Treatment with Diphenylhydantoin

Carl Ellenberger, Ronald M. Burde, John L Keltner

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Previous reports have suggested that diphenylhydantoin may improve visual field loss resulting from ischemic disease of the optic nerves. Therefore, 15 patients with residual visual impairment after acute, presumably ischemic, optic neuropathy were treated alternately with diphenylhydantoin sodium and placebo in a double-blind study. Neither visual acuity nor visual fields improved during treatment. The importance of careful quantitative perimetry with preliminary repetitive testing until results are reproducible is stressed.

Original languageEnglish (US)
Pages (from-to)435-438
Number of pages4
JournalArchives of Ophthalmology
Issue number6
StatePublished - 1974
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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