Acute myocardial infarction in hemoglobin SC disease

Henry Wang; Lawrence J. Laslett; Carol M Richman; Theodore Wun

doi:10.1007/s00277-004-0907-2

Acute myocardial infarction in hemoglobin SC disease

Henry Wang, Lawrence J. Laslett, Carol M Richman, Theodore Wun

Hematology and Oncology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Although there are reports of myocardial infarction (MI) in patients with sickle cell diseases, an antemortem diagnosis of acute MI in a patient with compound heterozygous hemoglobin SC disease has not been reported. Herein, we present a patient with hemoglobin SC who suffered an acute MI. She had typical chest pain for myocardial ischemia, associated with ST elevations on the electrocardiogram (EKG) and elevations of cardiac injury markers diagnostic of infarction. The patient was treated with conventional therapies for acute coronary syndrome and also emergent red blood cell exchange. Interestingly, coronary angiography was completely normal in this patient. Potential mechanisms and management for acute MI in patients with sickle cell disease are discussed.

Original language	English (US)
Pages (from-to)	622-624
Number of pages	3
Journal	Annals of Hematology
Volume	83
Issue number	10
DOIs	https://doi.org/10.1007/s00277-004-0907-2
State	Published - Oct 2004

Keywords

Diagnosis
Hemoglobin SC disease
Myocardial infarction
Treatment

ASJC Scopus subject areas

Hematology

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abstract = "Although there are reports of myocardial infarction (MI) in patients with sickle cell diseases, an antemortem diagnosis of acute MI in a patient with compound heterozygous hemoglobin SC disease has not been reported. Herein, we present a patient with hemoglobin SC who suffered an acute MI. She had typical chest pain for myocardial ischemia, associated with ST elevations on the electrocardiogram (EKG) and elevations of cardiac injury markers diagnostic of infarction. The patient was treated with conventional therapies for acute coronary syndrome and also emergent red blood cell exchange. Interestingly, coronary angiography was completely normal in this patient. Potential mechanisms and management for acute MI in patients with sickle cell disease are discussed.",

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T1 - Acute myocardial infarction in hemoglobin SC disease

AU - Wang, Henry

AU - Laslett, Lawrence J.

AU - Richman, Carol M

AU - Wun, Theodore

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N2 - Although there are reports of myocardial infarction (MI) in patients with sickle cell diseases, an antemortem diagnosis of acute MI in a patient with compound heterozygous hemoglobin SC disease has not been reported. Herein, we present a patient with hemoglobin SC who suffered an acute MI. She had typical chest pain for myocardial ischemia, associated with ST elevations on the electrocardiogram (EKG) and elevations of cardiac injury markers diagnostic of infarction. The patient was treated with conventional therapies for acute coronary syndrome and also emergent red blood cell exchange. Interestingly, coronary angiography was completely normal in this patient. Potential mechanisms and management for acute MI in patients with sickle cell disease are discussed.

AB - Although there are reports of myocardial infarction (MI) in patients with sickle cell diseases, an antemortem diagnosis of acute MI in a patient with compound heterozygous hemoglobin SC disease has not been reported. Herein, we present a patient with hemoglobin SC who suffered an acute MI. She had typical chest pain for myocardial ischemia, associated with ST elevations on the electrocardiogram (EKG) and elevations of cardiac injury markers diagnostic of infarction. The patient was treated with conventional therapies for acute coronary syndrome and also emergent red blood cell exchange. Interestingly, coronary angiography was completely normal in this patient. Potential mechanisms and management for acute MI in patients with sickle cell disease are discussed.

KW - Diagnosis

KW - Hemoglobin SC disease

KW - Myocardial infarction

KW - Treatment

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