Abstract
We investigated whether a diet of increased carbohydrate content reduces the symptoms of acute mountain sickness (AMS) and whether concentrations of circulating cytokines rise and correlate with hypoxia and AMS. There were 19 healthy volunteers who ingested in randomized order both a high carbohydrate (68% CHO) or normal carbohydrate (45% CHO) diet for 4 d. On the 4th d, subjects were exposed to 8 h of 10% normobaric oxygen. Each subject completed the Lake Louise Consensus Questionnaire (LLCQ: a questionnaire developed to quantify the common symptoms and consequences of AMS) at the beginning and end of each hypoxic session, at which times venous blood was obtained for the following cytokines: interleukins 1 beta, 6 and 8 (IL-1β, IL-6, IL-8) and tumor necrosis factor alpha (TNF-α). AMS symptoms did not differ significantly between the diets (LLCQ scores: 68% CHO = 10.1 ± 3.8 vs. 45% CHO = 10.3 ± 4.1). Cytokine concentrations did not change with hypoxia on either diet, nor did individual changes correlate with AMS symptoms. We conclude that a high carbohydrate diet for 4 d does not reduce the symptoms of AMS; and plasma cytokine concentrations do not change with hypoxia and the development of AMS and, thus, are not likely mediators of this syndrome.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 499-503 |
| Number of pages | 5 |
| Journal | Aviation Space and Environmental Medicine |
| Volume | 68 |
| Issue number | 6 |
| State | Published - Jun 1997 |
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ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Pollution
- Medicine(all)
Cite this
Acute mountain sickness is not altered by a high carbohydrate diet nor associated with elevated circulating cytokines. / Swenson, Erik R.; MacDonald, Alistair; Vatheuer, Martin; Maks, Christine; Treadwell, Allen; Allen, Roblee; Schoene, Robert B.
In: Aviation Space and Environmental Medicine, Vol. 68, No. 6, 06.1997, p. 499-503.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute mountain sickness is not altered by a high carbohydrate diet nor associated with elevated circulating cytokines
AU - Swenson, Erik R.
AU - MacDonald, Alistair
AU - Vatheuer, Martin
AU - Maks, Christine
AU - Treadwell, Allen
AU - Allen, Roblee
AU - Schoene, Robert B.
PY - 1997/6
Y1 - 1997/6
N2 - We investigated whether a diet of increased carbohydrate content reduces the symptoms of acute mountain sickness (AMS) and whether concentrations of circulating cytokines rise and correlate with hypoxia and AMS. There were 19 healthy volunteers who ingested in randomized order both a high carbohydrate (68% CHO) or normal carbohydrate (45% CHO) diet for 4 d. On the 4th d, subjects were exposed to 8 h of 10% normobaric oxygen. Each subject completed the Lake Louise Consensus Questionnaire (LLCQ: a questionnaire developed to quantify the common symptoms and consequences of AMS) at the beginning and end of each hypoxic session, at which times venous blood was obtained for the following cytokines: interleukins 1 beta, 6 and 8 (IL-1β, IL-6, IL-8) and tumor necrosis factor alpha (TNF-α). AMS symptoms did not differ significantly between the diets (LLCQ scores: 68% CHO = 10.1 ± 3.8 vs. 45% CHO = 10.3 ± 4.1). Cytokine concentrations did not change with hypoxia on either diet, nor did individual changes correlate with AMS symptoms. We conclude that a high carbohydrate diet for 4 d does not reduce the symptoms of AMS; and plasma cytokine concentrations do not change with hypoxia and the development of AMS and, thus, are not likely mediators of this syndrome.
AB - We investigated whether a diet of increased carbohydrate content reduces the symptoms of acute mountain sickness (AMS) and whether concentrations of circulating cytokines rise and correlate with hypoxia and AMS. There were 19 healthy volunteers who ingested in randomized order both a high carbohydrate (68% CHO) or normal carbohydrate (45% CHO) diet for 4 d. On the 4th d, subjects were exposed to 8 h of 10% normobaric oxygen. Each subject completed the Lake Louise Consensus Questionnaire (LLCQ: a questionnaire developed to quantify the common symptoms and consequences of AMS) at the beginning and end of each hypoxic session, at which times venous blood was obtained for the following cytokines: interleukins 1 beta, 6 and 8 (IL-1β, IL-6, IL-8) and tumor necrosis factor alpha (TNF-α). AMS symptoms did not differ significantly between the diets (LLCQ scores: 68% CHO = 10.1 ± 3.8 vs. 45% CHO = 10.3 ± 4.1). Cytokine concentrations did not change with hypoxia on either diet, nor did individual changes correlate with AMS symptoms. We conclude that a high carbohydrate diet for 4 d does not reduce the symptoms of AMS; and plasma cytokine concentrations do not change with hypoxia and the development of AMS and, thus, are not likely mediators of this syndrome.
UR - http://www.scopus.com/inward/record.url?scp=0030951325&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030951325&partnerID=8YFLogxK
M3 - Article
C2 - 9184737
AN - SCOPUS:0030951325
VL - 68
SP - 499
EP - 503
JO - Aerospace medicine and human performance
JF - Aerospace medicine and human performance
SN - 2375-6314
IS - 6
ER -