Acute mountain sickness is not altered by a high carbohydrate diet nor associated with elevated circulating cytokines

Erik R. Swenson, Alistair MacDonald, Martin Vatheuer, Christine Maks, Allen Treadwell, Roblee Allen, Robert B. Schoene

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

We investigated whether a diet of increased carbohydrate content reduces the symptoms of acute mountain sickness (AMS) and whether concentrations of circulating cytokines rise and correlate with hypoxia and AMS. There were 19 healthy volunteers who ingested in randomized order both a high carbohydrate (68% CHO) or normal carbohydrate (45% CHO) diet for 4 d. On the 4th d, subjects were exposed to 8 h of 10% normobaric oxygen. Each subject completed the Lake Louise Consensus Questionnaire (LLCQ: a questionnaire developed to quantify the common symptoms and consequences of AMS) at the beginning and end of each hypoxic session, at which times venous blood was obtained for the following cytokines: interleukins 1 beta, 6 and 8 (IL-1β, IL-6, IL-8) and tumor necrosis factor alpha (TNF-α). AMS symptoms did not differ significantly between the diets (LLCQ scores: 68% CHO = 10.1 ± 3.8 vs. 45% CHO = 10.3 ± 4.1). Cytokine concentrations did not change with hypoxia on either diet, nor did individual changes correlate with AMS symptoms. We conclude that a high carbohydrate diet for 4 d does not reduce the symptoms of AMS; and plasma cytokine concentrations do not change with hypoxia and the development of AMS and, thus, are not likely mediators of this syndrome.

Original languageEnglish (US)
Pages (from-to)499-503
Number of pages5
JournalAviation Space and Environmental Medicine
Volume68
Issue number6
StatePublished - Jun 1997

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Altitude Sickness
Carbohydrates
Nutrition
Cytokines
Diet
Interleukin-8
Lakes
Blood
Interleukin-1beta
Interleukin-1
Plasmas
Interleukin-6
Oxygen
Healthy Volunteers
Tumor Necrosis Factor-alpha

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Pollution
  • Medicine(all)

Cite this

Swenson, E. R., MacDonald, A., Vatheuer, M., Maks, C., Treadwell, A., Allen, R., & Schoene, R. B. (1997). Acute mountain sickness is not altered by a high carbohydrate diet nor associated with elevated circulating cytokines. Aviation Space and Environmental Medicine, 68(6), 499-503.

Acute mountain sickness is not altered by a high carbohydrate diet nor associated with elevated circulating cytokines. / Swenson, Erik R.; MacDonald, Alistair; Vatheuer, Martin; Maks, Christine; Treadwell, Allen; Allen, Roblee; Schoene, Robert B.

In: Aviation Space and Environmental Medicine, Vol. 68, No. 6, 06.1997, p. 499-503.

Research output: Contribution to journalArticle

Swenson, ER, MacDonald, A, Vatheuer, M, Maks, C, Treadwell, A, Allen, R & Schoene, RB 1997, 'Acute mountain sickness is not altered by a high carbohydrate diet nor associated with elevated circulating cytokines', Aviation Space and Environmental Medicine, vol. 68, no. 6, pp. 499-503.
Swenson, Erik R. ; MacDonald, Alistair ; Vatheuer, Martin ; Maks, Christine ; Treadwell, Allen ; Allen, Roblee ; Schoene, Robert B. / Acute mountain sickness is not altered by a high carbohydrate diet nor associated with elevated circulating cytokines. In: Aviation Space and Environmental Medicine. 1997 ; Vol. 68, No. 6. pp. 499-503.
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