Acute lung injury in the acute care surgery patient

Brittany Busse, Christine S Cocanour

Research output: Chapter in Book/Report/Conference proceedingChapter


Acute lung injury (ALI) is a spectrum of pulmonary insufficiency ranging from minor and easily correctable hypoxemia to severe refractory respiratory failure or acute respiratory distress syndrome (ARDS). The American-European Consensus Conference on ARDS in 1994 defined ALI as a syndrome of inflammation and increased permeability that is associated with a constellation of clinical, radiologic, and physiologic abnormalities that cannot be explained by, but may coexist with, left atrial or pulmonary capillary hypertension [1]. The resultant pulmonary insufficiency can be an indirect result of a systemic inflammatory state (circulating inflammatory mediators causing reactivity and edema in the lung parenchyma), or a direct result of a localized release of inflammatory mediators from a process affecting the lung parenchyma such as blunt chest trauma, toxic inhalation, aspiration, or pneumonia. Factors increasing a patient's likelihood of developing ALI are those that predispose a patient to massive inflammation, as well as increasing age, preexisting need for mechanical ventilation, smoke inhalation, massive transfusion, and drug overdose.

Original languageEnglish (US)
Title of host publicationCommon Problems in Acute Care Surgery
PublisherSpringer New York
Number of pages10
ISBN (Print)9781461461234, 1461461227, 9781461461227
StatePublished - Jul 1 2013

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Acute lung injury in the acute care surgery patient'. Together they form a unique fingerprint.

Cite this