Acute insulin response to glucagon, tolbutamide, and glucose in non-insulin-dependent diabetes of the young

C. Naidoo; I. Jialal; A. Suleman; M. C. Rajput; S. M. Joubert

Acute insulin response to glucagon, tolbutamide, and glucose in non-insulin-dependent diabetes of the young

C. Naidoo, I. Jialal, A. Suleman, M. C. Rajput, S. M. Joubert

Research output: Contribution to journal › Article › peer-review

Abstract

Acute insulin release in response to maximal intravenous doses of glucose (0.5 g/kg), tolbutamide (1 g), and glucagon (1 mg) was studied in 10 subjects with non-insulin-dependent diabetes of the young (NIDDY) and 10 age-, sex-, and weight-matched controls. Diabetic subjects had attenuated insulinemic responses to all three stimuli, in comparison with control subjects. However, insulin responses to glucagon and tolbutamide were higher than those obtained with intravenous glucose. This study demonstrates that the pancreatic β-cell is more responsive to nonglucose secretagogues than to glucose stimuli in individuals with NIDDY.

Original language	English (US)
Pages (from-to)	57-60
Number of pages	4
Journal	Diabetes Care
Volume	9
Issue number	1
State	Published - 1986
Externally published	Yes

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

Access to Document

Fingerprint Dive into the research topics of 'Acute insulin response to glucagon, tolbutamide, and glucose in non-insulin-dependent diabetes of the young'. Together they form a unique fingerprint.

Cite this

@article{f9f0329156e54e36befc576ef19f5a3a,

title = "Acute insulin response to glucagon, tolbutamide, and glucose in non-insulin-dependent diabetes of the young",

abstract = "Acute insulin release in response to maximal intravenous doses of glucose (0.5 g/kg), tolbutamide (1 g), and glucagon (1 mg) was studied in 10 subjects with non-insulin-dependent diabetes of the young (NIDDY) and 10 age-, sex-, and weight-matched controls. Diabetic subjects had attenuated insulinemic responses to all three stimuli, in comparison with control subjects. However, insulin responses to glucagon and tolbutamide were higher than those obtained with intravenous glucose. This study demonstrates that the pancreatic β-cell is more responsive to nonglucose secretagogues than to glucose stimuli in individuals with NIDDY.",

author = "C. Naidoo and I. Jialal and A. Suleman and Rajput, {M. C.} and Joubert, {S. M.}",

year = "1986",

language = "English (US)",

volume = "9",

pages = "57--60",

journal = "Diabetes Care",

issn = "1935-5548",

publisher = "American Diabetes Association Inc.",

number = "1",

}

TY - JOUR

T1 - Acute insulin response to glucagon, tolbutamide, and glucose in non-insulin-dependent diabetes of the young

AU - Naidoo, C.

AU - Jialal, I.

AU - Suleman, A.

AU - Rajput, M. C.

AU - Joubert, S. M.

PY - 1986

Y1 - 1986

N2 - Acute insulin release in response to maximal intravenous doses of glucose (0.5 g/kg), tolbutamide (1 g), and glucagon (1 mg) was studied in 10 subjects with non-insulin-dependent diabetes of the young (NIDDY) and 10 age-, sex-, and weight-matched controls. Diabetic subjects had attenuated insulinemic responses to all three stimuli, in comparison with control subjects. However, insulin responses to glucagon and tolbutamide were higher than those obtained with intravenous glucose. This study demonstrates that the pancreatic β-cell is more responsive to nonglucose secretagogues than to glucose stimuli in individuals with NIDDY.

AB - Acute insulin release in response to maximal intravenous doses of glucose (0.5 g/kg), tolbutamide (1 g), and glucagon (1 mg) was studied in 10 subjects with non-insulin-dependent diabetes of the young (NIDDY) and 10 age-, sex-, and weight-matched controls. Diabetic subjects had attenuated insulinemic responses to all three stimuli, in comparison with control subjects. However, insulin responses to glucagon and tolbutamide were higher than those obtained with intravenous glucose. This study demonstrates that the pancreatic β-cell is more responsive to nonglucose secretagogues than to glucose stimuli in individuals with NIDDY.

UR - http://www.scopus.com/inward/record.url?scp=0022589366&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022589366&partnerID=8YFLogxK

M3 - Article

C2 - 3512209

AN - SCOPUS:0022589366

VL - 9

SP - 57

EP - 60

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 1

ER -