Acute fibrinous and organizing pneumonia associated with allogenic hematopoietic stem cell transplant successfully treated with corticosteroids: A two-patient case series

Lam Phuong Nguyen, Stella Ahdoot, Narin Sriratanaviriyakul, Yanhong Zhang, Nicholas Stollenwerk, Michael Schivo, Richart W Harper

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14 Scopus citations


Acute fibrinous and organizing pneumonia (AFOP) is an extremely rare, relatively new, and distinct histological pattern of acute lung injury characterized predominately by the presence of intra-alveolar fibrin and associated organizing pneumonia. AFOP may be idiopathic or associated with a wide spectrum of clinical conditions. It has a variable clinical presentation from mild respiratory symptoms to that similar to the acute respiratory distress syndrome. Currently there is no consensus on treatment, and corticosteroids previously were of unclear benefit. To date, there are less than 40 cases of AFOP reported in the literature and only one has been linked to hematopoietic stem cell transplantation. Here we report the first case series of 2 patients who developed AFOP following allogenic stem cell transplant that were successfully treated with high-dose corticosteroids.

Original languageEnglish (US)
JournalJournal of Investigative Medicine High Impact Case Reports
Issue number2
StatePublished - Jan 1 2016



  • AFOP
  • Allogenic stem cell transplant
  • ARDS
  • BOOP
  • Diffuse alveolar damage

ASJC Scopus subject areas

  • Epidemiology
  • Safety, Risk, Reliability and Quality
  • Safety Research

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