TY - JOUR
T1 - Acute erosive gastritis induced by aspirin, ketoprofen, ibuprofen, and naproxen
T2 - Its prevention by metiamide and cimetidine
AU - Mann, Nirmal S
AU - Sachdev, A. J.
PY - 1977
Y1 - 1977
N2 - Aspirin, ketoprofen, ibuprofen, and naproxen all produced acute gastric erosions in rats. Aspirin produced significantly more erosions than ketoprofen, ibuprofen, or naproxen. There was no significant difference between the effects of ketoprofen, ibuprofen, and naproxen. Aspirin and naproxen produced a synergistic effect at higher dosage. Metiamide and cimetidine were effective in preventing this type of experimental acute erosive gastritis.
AB - Aspirin, ketoprofen, ibuprofen, and naproxen all produced acute gastric erosions in rats. Aspirin produced significantly more erosions than ketoprofen, ibuprofen, or naproxen. There was no significant difference between the effects of ketoprofen, ibuprofen, and naproxen. Aspirin and naproxen produced a synergistic effect at higher dosage. Metiamide and cimetidine were effective in preventing this type of experimental acute erosive gastritis.
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M3 - Article
C2 - 16348
AN - SCOPUS:0017686410
VL - 70
SP - 562
EP - 564
JO - Southern Medical Journal
JF - Southern Medical Journal
SN - 0038-4348
IS - 5
ER -