Acute erosive gastritis induced by aspirin, ketoprofen, ibuprofen, and naproxen: Its prevention by metiamide and cimetidine

Nirmal S Mann, A. J. Sachdev

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Aspirin, ketoprofen, ibuprofen, and naproxen all produced acute gastric erosions in rats. Aspirin produced significantly more erosions than ketoprofen, ibuprofen, or naproxen. There was no significant difference between the effects of ketoprofen, ibuprofen, and naproxen. Aspirin and naproxen produced a synergistic effect at higher dosage. Metiamide and cimetidine were effective in preventing this type of experimental acute erosive gastritis.

Original languageEnglish (US)
Pages (from-to)562-564
Number of pages3
JournalSouthern Medical Journal
Volume70
Issue number5
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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