Acute enteral manganese intoxication with hepatic failure due to ingestion of a joint supplement overdose

Angela Borchers, Steven E Epstein, Blaz Gindiciosi, Andrew Cartoceti, Birgit Puschner

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Manganese is a ubiquitous, essential trace element and a common ingredient of joint supplement tablets. Little information is known about the inherent toxic potential if ingested at higher doses. A 5-year-old female spayed Pug dog presented for evaluation of vomiting and ataxia after accidental ingestion of approximately 100 joint supplement tablets. The dog developed acute hepatic failure and was euthanized 6 days after presentation due to progression of the disease. Necropsy showed severe acute hepatic necrosis. Liver and kidney samples were submitted for toxicology analysis, results of which showed severely elevated manganese concentrations in the liver and kidneys.

Original languageEnglish (US)
Pages (from-to)658-663
Number of pages6
JournalJournal of Veterinary Diagnostic Investigation
Volume26
Issue number5
DOIs
StatePublished - Sep 1 2014

Keywords

  • Dogs
  • intoxication
  • manganese

ASJC Scopus subject areas

  • veterinary(all)

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