ACUTE CUTANEOUS GRAFT VERSUS HOST DISEASE: A CLINICOPATHOLOGIC AND IMMUNOPHENOTYPIC STUDY

Siba P Raychaudhuri; BRUCE R. SMOLLER

doi:10.1111/j.1365-4362.1992.tb03569.x

ACUTE CUTANEOUS GRAFT VERSUS HOST DISEASE: A CLINICOPATHOLOGIC AND IMMUNOPHENOTYPIC STUDY

Siba P Raychaudhuri, BRUCE R. SMOLLER

Research output: Contribution to journal › Article

15 Scopus citations

Abstract

Acute graft versus host disease (GVHD) is a major complication of bone marrow transplantation. This study was undertaken to characterize the histopathologic alterations in early lesions of GVHD and to improve our understanding about the disease process. Histopathologic and immunoperoxidase studies of skin tissue were carried out in 20 patients of GVHD. Sixty percent had grade II histopathologic changes in the skin, grade I and III changes were observed in 35% and 5% respectively. Follicular involvement could be observed in all cases beyond grade I. Immunoperoxidase study revealed 0PD4 (+) (T‐helper) cells in dermis and 0PD4 (−) (probably cytotoxic/suppressor) cells in epidermis.

Original language	English (US)
Pages (from-to)	270-272
Number of pages	3
Journal	International Journal of Dermatology
Volume	31
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-4362.1992.tb03569.x
State	Published - Jan 1 1992
Externally published	Yes

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ASJC Scopus subject areas

Dermatology

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Raychaudhuri, S. P., & SMOLLER, BRUCE. R. (1992). ACUTE CUTANEOUS GRAFT VERSUS HOST DISEASE: A CLINICOPATHOLOGIC AND IMMUNOPHENOTYPIC STUDY. International Journal of Dermatology, 31(4), 270-272. https://doi.org/10.1111/j.1365-4362.1992.tb03569.x

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10.1111/j.1365-4362.1992.tb03569.x