ACUTE CUTANEOUS GRAFT VERSUS HOST DISEASE: A CLINICOPATHOLOGIC AND IMMUNOPHENOTYPIC STUDY

Siba P Raychaudhuri, BRUCE R. SMOLLER

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Acute graft versus host disease (GVHD) is a major complication of bone marrow transplantation. This study was undertaken to characterize the histopathologic alterations in early lesions of GVHD and to improve our understanding about the disease process. Histopathologic and immunoperoxidase studies of skin tissue were carried out in 20 patients of GVHD. Sixty percent had grade II histopathologic changes in the skin, grade I and III changes were observed in 35% and 5% respectively. Follicular involvement could be observed in all cases beyond grade I. Immunoperoxidase study revealed 0PD4 (+) (T‐helper) cells in dermis and 0PD4 (−) (probably cytotoxic/suppressor) cells in epidermis.

Original languageEnglish (US)
Pages (from-to)270-272
Number of pages3
JournalInternational Journal of Dermatology
Volume31
Issue number4
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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