TY - JOUR
T1 - ACUTE CUTANEOUS GRAFT VERSUS HOST DISEASE
T2 - A CLINICOPATHOLOGIC AND IMMUNOPHENOTYPIC STUDY
AU - Raychaudhuri, Siba P
AU - SMOLLER, BRUCE R.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - Acute graft versus host disease (GVHD) is a major complication of bone marrow transplantation. This study was undertaken to characterize the histopathologic alterations in early lesions of GVHD and to improve our understanding about the disease process. Histopathologic and immunoperoxidase studies of skin tissue were carried out in 20 patients of GVHD. Sixty percent had grade II histopathologic changes in the skin, grade I and III changes were observed in 35% and 5% respectively. Follicular involvement could be observed in all cases beyond grade I. Immunoperoxidase study revealed 0PD4 (+) (T‐helper) cells in dermis and 0PD4 (−) (probably cytotoxic/suppressor) cells in epidermis.
AB - Acute graft versus host disease (GVHD) is a major complication of bone marrow transplantation. This study was undertaken to characterize the histopathologic alterations in early lesions of GVHD and to improve our understanding about the disease process. Histopathologic and immunoperoxidase studies of skin tissue were carried out in 20 patients of GVHD. Sixty percent had grade II histopathologic changes in the skin, grade I and III changes were observed in 35% and 5% respectively. Follicular involvement could be observed in all cases beyond grade I. Immunoperoxidase study revealed 0PD4 (+) (T‐helper) cells in dermis and 0PD4 (−) (probably cytotoxic/suppressor) cells in epidermis.
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U2 - 10.1111/j.1365-4362.1992.tb03569.x
DO - 10.1111/j.1365-4362.1992.tb03569.x
M3 - Article
C2 - 1634293
AN - SCOPUS:0026581256
VL - 31
SP - 270
EP - 272
JO - International Journal of Dermatology
JF - International Journal of Dermatology
SN - 0011-9059
IS - 4
ER -