Actomyosin contraction, aggregation and traveling waves in a treadmilling actin array

Dietmar Oelz, Alex Mogilner

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We use perturbation theory to derive a continuum model for the dynamic actomyosin bundle/ring in the regime of very strong crosslinking. Actin treadmilling is essential for contraction. Linear stability analysis and numerical solutions of the model equations reveal that when the actin treadmilling is very slow, actin and myosin aggregate into equidistantly spaced peaks. When treadmilling is significant, actin filament of one polarity are distributed evenly, while filaments of the opposite polarity develop a shock wave moving with the treadmilling velocity. Myosin aggregates into a sharp peak surfing the crest of the actin wave. Any actomyosin aggregation diminishes contractile stress. The easiest way to maintain higher contraction is to upregulate the actomyosin turnover which destabilizes nontrivial patterns and stabilizes the homogeneous actomyosin distributions. We discuss the model's implications for the experiment.

Original languageEnglish (US)
JournalPhysica D: Nonlinear Phenomena
DOIs
StateAccepted/In press - Jul 7 2015
Externally publishedYes

Fingerprint

traveling waves
contraction
myosins
filaments
polarity
crosslinking
bundles
shock waves
perturbation theory
continuums
rings

Keywords

  • Constriction ring
  • Continuum model
  • Myosin contraction

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Statistical and Nonlinear Physics

Cite this

Actomyosin contraction, aggregation and traveling waves in a treadmilling actin array. / Oelz, Dietmar; Mogilner, Alex.

In: Physica D: Nonlinear Phenomena, 07.07.2015.

Research output: Contribution to journalArticle

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