Activity and passive-avoidance learning in cobalt-injected rats

Michael Czarnota, Douglas Whitman, Robert F Berman

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A wide range of cognitive-behavioral sequelae, including memory deficits, results from hard metal disease in humans. Cobalt is a common component in the manufacture of hard metals and is a biologically active, toxic substance. This study examined the effects of cobalt exposure in rats. Results showed decreased exploratory behavior and a trend for higher-dose subjects to show decreased passive avoidance learning. No significant differences in active maze learning were found. These results indicate the value of further explorations of the cognitive-behavioral effects of cobalt exposure and suggest a number of methodological cautions.

Original languageEnglish (US)
Pages (from-to)29-34
Number of pages6
JournalInternational Journal of Neuroscience
Volume93
Issue number1-2
StatePublished - Feb 1998
Externally publishedYes

Fingerprint

Avoidance Learning
Cobalt
Maze Learning
Problem-Based Learning
Exploratory Behavior
Poisons
Memory Disorders
hard metal

Keywords

  • Cobalt
  • Hard metal disease
  • Learning deficits
  • Metal toxicity
  • Occupational toxicity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Activity and passive-avoidance learning in cobalt-injected rats. / Czarnota, Michael; Whitman, Douglas; Berman, Robert F.

In: International Journal of Neuroscience, Vol. 93, No. 1-2, 02.1998, p. 29-34.

Research output: Contribution to journalArticle

Czarnota, Michael ; Whitman, Douglas ; Berman, Robert F. / Activity and passive-avoidance learning in cobalt-injected rats. In: International Journal of Neuroscience. 1998 ; Vol. 93, No. 1-2. pp. 29-34.
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