Activity and passive-avoidance learning in cobalt-injected rats

Michael Czarnota, Douglas Whitman, Robert F Berman

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


A wide range of cognitive-behavioral sequelae, including memory deficits, results from hard metal disease in humans. Cobalt is a common component in the manufacture of hard metals and is a biologically active, toxic substance. This study examined the effects of cobalt exposure in rats. Results showed decreased exploratory behavior and a trend for higher-dose subjects to show decreased passive avoidance learning. No significant differences in active maze learning were found. These results indicate the value of further explorations of the cognitive-behavioral effects of cobalt exposure and suggest a number of methodological cautions.

Original languageEnglish (US)
Pages (from-to)29-34
Number of pages6
JournalInternational Journal of Neuroscience
Issue number1-2
StatePublished - Feb 1998
Externally publishedYes


  • Cobalt
  • Hard metal disease
  • Learning deficits
  • Metal toxicity
  • Occupational toxicity

ASJC Scopus subject areas

  • Neuroscience(all)


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