Actively regulating bioengineered tissue and organ formation

David J. Mooney, T. Boontheekul, Ruth Chen, Jonathan K Leach

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Objectives : Describe current and future approaches to tissue engineering, specifically in the area of bone regeneration. These approaches will allow one to actively regulate the cellular populations participating in this process. Design : Many approaches to actively regulate cellular phenotype are under exploration, and these typically exploit known signal transduction pathways via presentation of specific receptor-binding ligands, and may also deliver mechanical information via the physical bridge formed by the receptor-ligand interactions. Cellular gene expression may also be directly modulated utilizing gene therapy approaches to control tissue regeneration. Conclusions : Significant progress has been made to date in bone regeneration using inductive molecules and transplanted cells, and FDA approved therapies have resulted. While approaches to date have focused on delivery of single stimuli (e.g. one growth factor), future efforts will likely attempt to more closely mimic developmental processes by the delivery of multiple inputs to the cells in spatially and temporally regulated fashions.

Original languageEnglish (US)
Pages (from-to)141-144
Number of pages4
JournalOrthodontics and Craniofacial Research
Issue number3
StatePublished - 2005
Externally publishedYes


  • Biomaterials
  • Extracellular matrix
  • Growth factors
  • Peptides

ASJC Scopus subject areas

  • Orthodontics
  • Oral Surgery
  • Otorhinolaryngology
  • Surgery


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