Activation of visceral thin-fiber afferents increases respiratory output in cats

Tony G. Waldrop, Kenneth J. Rybicki, Marc P Kaufman, George A. Ordway

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Respiratory responses to chemical activation of thin-fiber afferents from the stomach and the gallbladder were measured in anesthetized cats. Capsaicin or bradykinin applied to the serosal surface of either the stomach or the gallbladder elicited increases in breathing and phrenic nerve activity. Transection of the cervical vagi or the carotid sinus nerves had no effect on these responses. However, the respiratory responses to visceral stimulation were abolished by bilateral transection of the splanchnic nerves. We conclude that activation of thin-fiber afferents from the stomach and gallbladder causes a reflex increase in respiratory output. The initial afferent limb of this reflex is via the splanchnic nerves.

Original languageEnglish (US)
Pages (from-to)187-196
Number of pages10
JournalRespiration Physiology
Volume58
Issue number2
DOIs
StatePublished - 1984
Externally publishedYes

Keywords

  • Bradykinin
  • Capsaicin
  • Carotid sinus nerves
  • Cat
  • Phrenic nerve
  • Splanchnic nerves
  • Vagi
  • Ventilation
  • Visceral afferents

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

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